Back to Search
Start Over
Decreased levels of circulating CD34(+) cells are associated with coronary heart disease in Japanese patients with type 2 diabetes
- Source :
- Journal of Diabetes Investigation
- Publication Year :
- 2014
-
Abstract
- Aims/Introduction Circulating progenitor cells, including CD34 positive (CD34+) cells, play a key role in neovascularisation and the maintenance of vascular endothelial function. Several lines of evidence show an association between decreased levels of circulating CD34+ cells and cardiovascular disease. However, the contribution of circulating CD34+ cells to the occurrence of cardiovascular events in diabetic patients remains unclear. Materials and Methods In the present study with a median follow up of 4.6 years, we analyzed the level of circulating CD34+ cells in 192 patients with type 2 diabetes. The outcome variables were coronary heart disease (CHD) events (cardiovascular death, unstable angina, myocardial infarction, percutaneous coronary intervention or coronary artery bypass grafting) and cerebrovascular disease events (cerebral infarction, cerebral hemorrhage or transient ischemic attack). Results Decreased levels of circulating CD34+ cells were associated with a significantly higher incidence of CHD based on Kaplan–Meier analysis (P = 0.0052). After adjusting for age, sex, dyslipidemia, hypertension, glycated hemoglobin, history of cardiovascular disease, body mass index, and statin and renin angiotensin system inhibitors use, decreased levels of CD34+ cells were significantly associated with the incidence of CHD events (hazard ratio of low tertile 2.61, 95% confidence interval 1.22–5.96; P = 0.013, reference; high tertile). Conclusions Decreased levels of circulating CD34+ cells might predict CHD events in patients with diabetes, and this could be useful for identifying patients with diabetes at high risk of cardiovascular events.
- Subjects :
- medicine.medical_specialty
Statin
medicine.drug_class
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Type 2 diabetes
chemistry.chemical_compound
Circulating progenitor cell
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Myocardial infarction
business.industry
Unstable angina
Percutaneous coronary intervention
Endothelial function
General Medicine
Articles
medicine.disease
Coronary heart disease
chemistry
Cardiology
Glycated hemoglobin
business
Dyslipidemia
Subjects
Details
- ISSN :
- 20401116
- Volume :
- 6
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of diabetes investigation
- Accession number :
- edsair.doi.dedup.....9bbf29dab78444ac5a46279e1d4039b5