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The effect of strawberries in a cholesterol-lowering dietary portfolio
- Source :
- Metabolism: clinical and experimental. 57(12)
- Publication Year :
- 2008
-
Abstract
- Effective diets reduce blood lipids and oxidative damage, both of which have been linked to the complications of diabetes and coronary heart disease. Our objective was to assess the effect of adding strawberries, as a source of antioxidants, to improve the antioxidant effect of a cholesterol-lowering diet (dietary portfolio). To this end, 28 hyperlipidemic subjects who had followed the dietary portfolio consisting of soy, viscous fiber, plant sterol, and nuts for a mean of 2.5 years were randomized to receive supplements of strawberries (454 g/d, 112 kcal) or additional oat bran bread (65 g/d, 112 kcal, approximately 2 g beta-glucan) (control) in a randomized 1-month crossover study with a 2-week washout. Strawberry supplementation resulted in a greater reduction in oxidative damage to low-density lipoprotein (LDL) measured as thiobarbituric acid-reactive substances in the LDL fraction (P = .014). At the end of the strawberry period, reductions in LDL cholesterol and in the ratio of total to high-density lipoprotein cholesterol were maintained close to 1-year values at -13.4% +/- 2.1% and -15.2% +/- 1.7%, respectively (P < .001), and were similar to the post-oat bran bread values. Strawberries also improved the palatability of the diet. We conclude that strawberry supplementation reduced oxidative damage to LDL while maintaining reductions in blood lipids and enhancing diet palatability. Added fruit may improve the overall utility of diets designed to lower coronary heart disease risk.
- Subjects :
- Adult
Male
medicine.medical_specialty
Antioxidant
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Hypercholesterolemia
Blood lipids
Blood Pressure
Biology
Fragaria
Thiobarbituric Acid Reactive Substances
law.invention
Endocrinology
law
Internal medicine
Diabetes mellitus
medicine
Humans
Palatability
Diet, Fat-Restricted
Aged
Bran
Anticholesteremic Agents
food and beverages
Middle Aged
medicine.disease
Crossover study
Cholesterol
Patient Compliance
lipids (amino acids, peptides, and proteins)
Female
Phytotherapy
Oxidation-Reduction
Algorithms
Lipoprotein
Subjects
Details
- ISSN :
- 15328600
- Volume :
- 57
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Metabolism: clinical and experimental
- Accession number :
- edsair.doi.dedup.....9ba08c6d85491169762095b0b7355b32