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Gene-rich UV sex chromosomes harbor conserved regulators of sexual development
- Source :
- Science Advances, Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (27), pp.eabh2488. ⟨10.1126/sciadv.abh2488⟩, Science advances, vol 7, iss 27, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2021
- Publisher :
- American Association for the Advancement of Science, 2021.
-
Abstract
- Centro de Investigación Forestal (CIFOR)<br />Nonrecombining sex chromosomes, like the mammalian Y, often lose genes and accumulate transposable ele ments, a process termed degeneration. The correlation between suppressed recombination and degeneration is clear in animal XY systems, but the absence of recombination is confounded with other asymmetries between the X and Y. In contrast, UV sex chromosomes, like those found in bryophytes, experience symmetrical population genetic conditions. Here, we generate nearly gapless female and male chromosome-scale reference genomes of the moss Ceratodon purpureus to test for degeneration in the bryophyte UV sex chromosomes. We show that the moss sex chromosomes evolved over 300 million years ago and expanded via two chromosomal fusions. Although the sex chromosomes exhibit weaker purifying selection than autosomes, we find that suppressed recombination alone is insufficient to drive degeneration. Instead, the U and V sex chromosomes harbor thousands of broadly expressed genes, including numerous key regulators of sexual development across land plants.<br />This work was supported by NSF DEB-1541005 and 1542609 and start-up funds from UF to S.F.M.; microMORPH Cross-Disciplinary Training Grant, Sigma-Xi Grant-In-Aid of Research, and Society for the Study of Evolution Rosemary Grant Award to S.B.C.; NSF DEB-1239992 to N.J.W.; the Emil Aaltonen Foundation and the University of Turku to S.O.; and NSF DEB-1541506 to J.G.B. and S.F.M. The work conducted by the U.S. Department of Energy Joint Genome Institute was supported by the Office of Science of the U.S. Department of Energy under contract no. DE-AC02-05CH11231.<br />12 Pág. Supplementary material for this article is available at http://advances.sciencemag.org/cgi/ content/full/7/27/eabh2488/DC1
- Subjects :
- 0106 biological sciences
Male
[SDV]Life Sciences [q-bio]
01 natural sciences
Genome
R Package
Negative selection
Research Articles
Genetics
Mammals
0303 health sciences
education.field_of_study
Multidisciplinary
Ceratodon purpureus
Sex Chromosomes
Phylogenetic analysis
biology
Sexual Development
Reveals
SciAdv r-articles
tool
3. Good health
CD-Hit
Female
Recombination
Research Article
Biotechnology
Transposable element
Evolution
1.1 Normal biological development and functioning
Population
Evolution, Molecular
03 medical and health sciences
Underpinning research
Complex
Sequence
Animals
education
Gene
030304 developmental biology
Evolutionary Biology
Autosome
Protein
Plant Sciences
Molecular
biology.organism_classification
DNA Transposable Elements
010606 plant biology & botany
Genome annotation
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Database :
- OpenAIRE
- Journal :
- Science Advances, Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (27), pp.eabh2488. ⟨10.1126/sciadv.abh2488⟩, Science advances, vol 7, iss 27, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....9b9c920b4f8df7e65719d8cdb223b42d
- Full Text :
- https://doi.org/10.1126/sciadv.abh2488⟩