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Gene-rich UV sex chromosomes harbor conserved regulators of sexual development

Authors :
Avinash Sreedasyam
Jerry Jenkins
Jacob B. Landis
Kerrie Barry
Stuart F. McDaniel
Sanna Olsson
Stefan A. Rensing
Jordan C. McBreen
Noe Fernandez-Pozo
J. Gordon Burleigh
Chris Daum
Matthew G. Johnson
Leslie M. Kollar
Christopher A. Saski
Adam Healey
Adam C. Payton
John T. Lovell
Jane Grimwood
Sanna Huttunen
Florian Maumus
Sarah B. Carey
Jeremy Schmutz
Anna Lipzen
Shengqiang Shu
Cindy Chen
Roth E. Conrad
Mei Wang
George P. Tiley
Norman J. Wickett
Society for the Study of Evolution (US)
Emil Aaltonen Foundation
University of Turku
Carey, Sarah B.
Jenkins, Jerry
Lovell, John T.
Maumus, Florian
Sreedasyam, Avinash
Shu, Shengqiang
Tiley, George P.
Fernandez-Pozo, Noe
Healey, Adam
Barry, Kerrie
Chen, Cindy
Lipzen, Anna
Daum, Chris
Saski, Christopher A.
McBreen, Jordan C.
Conrad, Roth E.
Kollar, Leslie M.
Olsson, Sanna
Huttunen, Sanna
Landis, Jacob B.
Burleigh, J. Gordon
Wickett, Norman J.
Matthew G Johnson
Rensing, Stefan A.
Unité de Recherche Génomique Info (URGI)
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Carey, Sarah B.[0000-0002-6431-0660]
Jenkins, Jerry [0000-0002-7943-3997]
Lovell, John T. [0000-0002-8938-1166]
Maumus, Florian [0000-0001-7325-0527]
Sreedasyam, Avinash [0000-0001-7336-7012]
Shu, Shengqiang [0000-0002-4336-8994]
Tiley, George P. [0000-0003-0053-0207]
Fernandez-Pozo, Noe [0000-0002-6489-5566]
Healey, Adam [0000-0002-3088-6856]
Barry, Kerrie [0000-0002-8999-6785]
Chen, Cindy [0000-0002-7539-103X]
Lipzen, Anna [0000-0003-2293-9329]
Daum, Chris [0000-0003-3895-5892]
Saski, Christopher A.[0000-0002-2780-4274]
McBreen, Jordan C.[0000-0001-8867-6483]
Conrad, Roth E.[Conrad, Roth E.]
Kollar, Leslie M.[0000-0001-8726-9085]
Olsson, Sanna [0000-0002-1199-4499]
Huttunen, Sanna [0000-0003-1374-9857]
Landis, Jacob B.[0000-0002-5631-5365]
Burleigh, J. Gordon [0000-0001-8120-5136]
Wickett, Norman J.[0000-0003-0944-1956]
Matthew G Johnson [0000-0002-1958-6334
Rensing, Stefan A. [0000-0002-0225-873X]
Source :
Science Advances, Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (27), pp.eabh2488. ⟨10.1126/sciadv.abh2488⟩, Science advances, vol 7, iss 27, Digital.CSIC. Repositorio Institucional del CSIC, instname
Publication Year :
2021
Publisher :
American Association for the Advancement of Science, 2021.

Abstract

Centro de Investigación Forestal (CIFOR)<br />Nonrecombining sex chromosomes, like the mammalian Y, often lose genes and accumulate transposable ele ments, a process termed degeneration. The correlation between suppressed recombination and degeneration is clear in animal XY systems, but the absence of recombination is confounded with other asymmetries between the X and Y. In contrast, UV sex chromosomes, like those found in bryophytes, experience symmetrical population genetic conditions. Here, we generate nearly gapless female and male chromosome-scale reference genomes of the moss Ceratodon purpureus to test for degeneration in the bryophyte UV sex chromosomes. We show that the moss sex chromosomes evolved over 300 million years ago and expanded via two chromosomal fusions. Although the sex chromosomes exhibit weaker purifying selection than autosomes, we find that suppressed recombination alone is insufficient to drive degeneration. Instead, the U and V sex chromosomes harbor thousands of broadly expressed genes, including numerous key regulators of sexual development across land plants.<br />This work was supported by NSF DEB-1541005 and 1542609 and start-up funds from UF to S.F.M.; microMORPH Cross-Disciplinary Training Grant, Sigma-Xi Grant-In-Aid of Research, and Society for the Study of Evolution Rosemary Grant Award to S.B.C.; NSF DEB-1239992 to N.J.W.; the Emil Aaltonen Foundation and the University of Turku to S.O.; and NSF DEB-1541506 to J.G.B. and S.F.M. The work conducted by the U.S. Department of Energy Joint Genome Institute was supported by the Office of Science of the U.S. Department of Energy under contract no. DE-AC02-05CH11231.<br />12 Pág. Supplementary material for this article is available at http://advances.sciencemag.org/cgi/ content/full/7/27/eabh2488/DC1

Details

Language :
English
ISSN :
23752548
Database :
OpenAIRE
Journal :
Science Advances, Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (27), pp.eabh2488. ⟨10.1126/sciadv.abh2488⟩, Science advances, vol 7, iss 27, Digital.CSIC. Repositorio Institucional del CSIC, instname
Accession number :
edsair.doi.dedup.....9b9c920b4f8df7e65719d8cdb223b42d
Full Text :
https://doi.org/10.1126/sciadv.abh2488⟩