Back to Search
Start Over
Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease
- Source :
- Current Opinion in Neurobiology. 21:920-928
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- The largest genetic risk for late-onset Alzheimer's disease (AD) resides at the apolipoprotein E gene (APOE) locus, which has three common alleles (ɛ2, ɛ3, ɛ4) that encode three isoforms (apoE2, apoE3, apoE4). The very strong association of the APOE ɛ4 allele with AD risk and its role in the accumulation of amyloid β in brains of people and animal models solidify the biological relevance of apoE isoforms but do not provide mechanistic insight. The innate immune response is consistently observed in AD and is a likely contributor to neuronal injury and response to injury. Here we review emerging data showing that apoE isoform regulation of multiple facets of the innate immune response in the brain may alter AD not only through amyloid β-dependent mechanisms, but also through other, amyloid β-independent mechanisms.
- Subjects :
- Gene isoform
Apolipoprotein E
Innate immune system
General Neuroscience
Locus (genetics)
Disease
Biology
medicine.disease
Article
Immunity, Innate
Apolipoproteins E
Alzheimer Disease
Immunology
medicine
Animals
Humans
Protein Isoforms
Genetic Predisposition to Disease
lipids (amino acids, peptides, and proteins)
Alzheimer's disease
Allele
Neuroscience
Subjects
Details
- ISSN :
- 09594388
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Neurobiology
- Accession number :
- edsair.doi.dedup.....9b94d46450292aa87d01118ef6fef587