Back to Search
Start Over
Impact of radiation techniques on lung toxicity in patients with mediastinal Hodgkin's lymphoma
- Source :
- Strahlentherapie Und Onkologie
- Publication Year :
- 2020
-
Abstract
- Purpose Mediastinal radiotherapy (RT), especially when combined with bleomycin, may result in substantial pulmonary morbidity and mortality. The use of modern RT techniques like intensity-modulated radiotherapy (IMRT) is gaining interest to spare organs at risk. Methods We evaluated 27 patients who underwent RT for Hodgkin’s lymphoma between 2009 and 2013 at our institution. For each patient, three different treatment plans for a 30-Gy involved-field RT (IFRT) were created (anterior-posterior-posterior-anterior setup [APPA], 5‑field IMRT, and 7‑field IMRT) and analyzed concerning their inherent “normal tissue complication probability” (NTCP) for pneumonitis and secondary pulmonary malignancy. Results The comparison of different radiation techniques showed a significant difference in favor of standard APPA (p p Conclusion Radiation-induced lung toxicity is rare after treatment for Hodgkin lymphoma but may be influenced significantly by the RT technique used. In this study, APPA RT plans demonstrated a decrease in potential radiation pneumonitis and pulmonary malignancies. Biological planning using NTCP may have the potential to define personalized RT strategies
- Subjects :
- 3D-CRT
Adult
Male
medicine.medical_specialty
Lung Neoplasms
Adolescent
Second malignancy
medicine.medical_treatment
Normal tissue complication probability
Bleomycin
Malignancy
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
IMRT
Pneumonitis
Aged
Aged, 80 and over
Biological evaluation
business.industry
Mediastinum
Neoplasms, Second Primary
Middle Aged
medicine.disease
Hodgkin's lymphoma
Hodgkin Disease
Confidence interval
Lymphoma
Radiation therapy
Radiation Pneumonitis
Oncology
chemistry
030220 oncology & carcinogenesis
Original Article
Female
Radiology
Radiotherapy, Intensity-Modulated
Radiotherapy, Conformal
Complication
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 1439099X
- Volume :
- 197
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Accession number :
- edsair.doi.dedup.....9b909ae822accde6b15f683106b90a99