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Beta amyloid aggregation inhibitors: small molecules as candidate drugs for therapy of Alzheimer's disease
- Source :
- Current medicinal chemistry. 17(27)
- Publication Year :
- 2010
-
Abstract
- The progressive production and subsequent accumulation of β-amyloid (Aβ), a proteolytic fragment of the membrane-associated amyloid precursor protein (APP), plays a central role in Alzheimer's Disease (AD). Aβ is released in a soluble form that may be responsible for cognitive dysfunction in the early stages of the disease, then progressively forms oligomeric, multimeric and fibrillar aggregates, triggering neurodegeneration. Eventually, the aggregation and accumulation of Aβ culminates with the formation of extracellular plaques, one of the morphological hallmarks of the disease, detectable post-mortem in AD brains. In this review we report the known structural features of amyloid peptides and fibrils, and we give an overview of all small molecules that have been found to interact with Aβ aggregation. Deeper knowledge of the mechanism leading to amyloid fibrils along with their molecular structure and the molecular interactions responsible for activity of small molecules could supply useful information for the design of new AD therapeutic agents.
- Subjects :
- Models, Molecular
Pathology
medicine.medical_specialty
Amyloid
Molecular Sequence Data
Aggregation inhibitor
Fibril
Biochemistry
Small Molecule Libraries
Amyloid beta-Protein Precursor
Alzheimer Disease
Drug Discovery
Amyloid precursor protein
medicine
Animals
Humans
Amino Acid Sequence
Pharmacology
biology
β-amyloid
Chemistry
Organic Chemistry
Neurodegeneration
P3 peptide
Alzheimer's disease
medicine.disease
Small molecule
Cell biology
Biochemistry of Alzheimer's disease
biology.protein
Molecular Medicine
Subjects
Details
- ISSN :
- 1875533X
- Volume :
- 17
- Issue :
- 27
- Database :
- OpenAIRE
- Journal :
- Current medicinal chemistry
- Accession number :
- edsair.doi.dedup.....9b8c7da5929e8abbf050aa96e6280669