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Origanum vulgare ssp. vulgare: Chemical Composition and Biological Studies
- Source :
- Molecules, Volume 23, Issue 8, Molecules, Vol 23, Iss 8, p 2077 (2018), Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
- Publication Year :
- 2018
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2018.
-
Abstract
- The biological properties and main phenolic compounds of the O. vulgare L. ssp. vulgare extract are described in the present paper. The polyphenolic compounds were analyzed by chromatographic and spectrophotometric techniques. The antioxidant potential was evaluated using several methods: CUPRAC (cupric ion reducing antioxidant capacity), FRAP (ferric reducing ability of plasma), inhibition of lipid peroxidation catalyzed by cytochrome c, and superoxide (SO) scavenging assays. The antimicrobial activity of the oregano extract was evaluated by means of agar-well diffusion assay. The hepatoprotective effect of the O. vulgare extract on CCl4-induced hepatotoxicity was evaluated in rats. Liver injury was estimated by determination of alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), gamma-glutamyl transferase GGT, total protein and albumin concentrations, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA). These values were improved by the administration of oregano extract. A specific phenolic profile was evidenced by these data, with large amounts of rosmarinic and chlorogenic acids. The oregano extract showed very strong antioxidant activity in good agreement with the phenolic content. Antimicrobial activity was good, especially against Salmonella enteritidis and Aspergillus niger strains. The high hepatoprotective, antioxidant and antimicrobial activity, along with polyphenol-rich content, can support the use of O. vulgare in therapy. We also expect our results to open new research directions for designing important new drug products, using indigenous plant material.
- Subjects :
- 0301 basic medicine
Antioxidant
antioxidant
medicine.medical_treatment
Pharmaceutical Science
hepatoprotective
01 natural sciences
Article
Analytical Chemistry
lcsh:QD241-441
Superoxide dismutase
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
lcsh:Organic chemistry
Drug Discovery
medicine
Food science
Physical and Theoretical Chemistry
polyphenols
chemistry.chemical_classification
biology
Chemistry
Origanum vulgare
Glutathione peroxidase
010401 analytical chemistry
Organic Chemistry
Origanum
cythocrome c
biology.organism_classification
Ferric reducing ability of plasma
0104 chemical sciences
030104 developmental biology
Chemistry (miscellaneous)
Catalase
Polyphenol
biology.protein
Molecular Medicine
antimicrobial
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....9b753474ed6566b6989cd14bb0a25ce5
- Full Text :
- https://doi.org/10.3390/molecules23082077