Back to Search
Start Over
Increased ventricular pacing threshold levels in patients with high serum uric acid levels
- Source :
- Journal of Cardiology. 64:207-210
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- PubMedID: 24560275 Background: Permanent cardiac pacemakers (PCM) are accepted as the most effective treatment for symptomatic bradyarrhythmias. Serum uric acid (UA) levels are associated with various inflammatory markers, oxidative stress, and endothelial dysfunction. This study aimed to investigate the association between serum UA and ventricular pacing threshold (VPT) levels in patients who underwent permanent pacemaker implantation. Materials and methods: We retrospectively analyzed a total of 198 patients who underwent PCM implantation for indications such as symptomatic bradycardia without a reversible etiology and high-degree and complete atrioventricular block. Results: VPT values were found to correlate with serum UA levels ( r= 0.591, p < 0.001), high sensitivity C-reactive protein (hs-CRP) levels (r= 0.505, p< 0.001), and ventricular impedance (r= 0.220, p= 0.016). The serum UA levels and hs-CRP levels were also correlated (r= 0.691, p < 0.001). To identify independent risk factors for VPT values, a multivariate linear regression model was conducted, and serum UA levels (ß= 0.361, p= 0.001), hs-CRP levels (ß= 0.277, p= 0.012), and impedance values (ß= 0.207, p= 0.011) were found to be independent risk factors for VPT. Conclusion: In the present study, VPT values at the time of implantation and at the 30th day were increased in patients with high serum UA levels. To further extend the life of pacemakers, as well as other factors that affect threshold values, serum UA levels should be noted. © 2014 Japanese College of Cardiology.
- Subjects :
- Male
Bradycardia
Pacemaker, Artificial
medicine.medical_specialty
Heart Ventricles
medicine.disease_cause
Permanent cardiac pacemakers
chemistry.chemical_compound
Internal medicine
medicine
Humans
In patient
Cardiac Output
Endothelial dysfunction
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Cardiac Pacing, Artificial
Middle Aged
Ventricular pacing
medicine.disease
Uric Acid
chemistry
Etiology
Cardiology
Uric acid
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Ventricular pacing threshold
Atrioventricular block
Biomarkers
Oxidative stress
Subjects
Details
- ISSN :
- 09145087
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....9b71353a8b53b593d416bdc5ada40e03
- Full Text :
- https://doi.org/10.1016/j.jjcc.2014.01.006