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The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:6107-6111
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- A novel series of [2.2.1]-azahydantoins has been designed and synthesized in an enantiospecific manner. The ability of these compounds to act as antagonists to the androgen receptor was investigated and several were found to have potent activity in vitro.
- Subjects :
- Models, Molecular
Cell Survival
medicine.drug_class
Clinical Biochemistry
Drug Evaluation, Preclinical
Molecular Conformation
Pharmaceutical Science
Pharmacology
Antiandrogen
Biochemistry
Chemical synthesis
Cell Line
Structure-Activity Relationship
Drug Discovery
Androgen Receptor Antagonists
medicine
Humans
Structure–activity relationship
Molecular Biology
Aza Compounds
Chemistry
Hydantoins
Organic Chemistry
Antagonist
In vitro
Androgen receptor
Evaluation Studies as Topic
Cell culture
Drug Design
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....9b6e0ec9aa6622f947e8f05d251584f5
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.09.049