Laparoscopic versus open gastrectomy for high-risk patients with gastric cancer: A systematic review and meta-analysis

It is still remains unclear whether high-risk patients with gastric cancer can benefit from the application of laparoscopic gastrectomy (LG). The aim of this systematic review was to evaluate the surgical and long-term outcomes after LG and open gastrectomy (OG) for high-risk patients with gastric cancer.We performed a systematic literature search in various databases from January 1994 to June 2018. Patients who had≥1 of the following conditions were defined as high-risk patients: (1) age≥70 years; (2) BMI≥30 kg/mIn the present meta-analysis, the outcomes of 12 non-randomized controlled studies enrolling 1651 patients (873 in the LG group and 778 in the OG group) were pooled. The estimated blood loss was significantly lower in the LG group than those in the OG group (P 0.01). There was no significant difference between two groups in operative time (P = 0.17) and number of harvested lymph nodes (P = 0.21). In the LG group, the time to flatus (P 0.01), time to food intake (P 0.01), and postoperative hospital stay (P 0.01) were significantly shorter than those in the OG group. A lower overall postoperative complication rate was observed in the LG group (P 0.01). The incidence of surgical (P 0.01) and non-surgical (P 0.01) complication was significantly lower in the LG group than that in the OG group. The pooled analysis showed no significant difference in overall survival (OS) between LG and OG groups (P = 0.98).LG can be a safe and feasible procedure for high-risk patients with gastric cancer.