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Serum HBsAg levels during peginterferon α-2a treatment with or without thymosin α-1 in HBeAg-positive chronic hepatitis B patients
- Source :
- Journal of medical virology. 83(1)
- Publication Year :
- 2010
-
Abstract
- The importance of serum hepatitis B surface antigen (HBsAg) level as a surrogate marker for viral load and a predictor of treatment response remains unclear. The aim of this study was to investigate whether serum HBsAg correlates with serum hepatitis B virus (HBV) DNA during peginterferon (PEG-IFN) α-2a treatment (with or without thymosin α-1) in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients and whether it can predict treatment response. Sera from 37 HBeAg-positive chronic hepatitis B patients receiving 48-weeks PEG-IFN α-2a with (n = 20) or without (n = 17) an initial 12-weeks thymosin α-1 were obtained at baseline and at weeks 12, 24, 36, 48 (end of treatment), 56, 72, 84, and 96 (end of follow-up). Taqman HBV DNA tests (Roche) and Architect HBsAg QT (Abbott) were performed. There was a moderate correlation between the HBsAg and HBV DNA levels (r = 0.452, P < 0.001). Median HBsAg levels at baseline and at week 96 were 6,218 IU/ml and 4,038 IU/ml, respectively. The mean HBV DNA and alanine aminotransferase (ALT) levels were 7.48 log(10) IU/ml and 173 IU/L at baseline and 5.37 log(10) IU/ml and 102 IU/L at week 96, respectively. A decrease to
- Subjects :
- Adult
Male
Serum
HBsAg
Thymalfasin
Interferon alpha-2
medicine.disease_cause
Polyethylene Glycols
Hepatitis B, Chronic
Orthohepadnavirus
Virology
medicine
Humans
Hepatitis B virus
Hepatitis B Surface Antigens
biology
business.industry
virus diseases
Interferon-alpha
Hepatitis B
Viral Load
medicine.disease
biology.organism_classification
digestive system diseases
Recombinant Proteins
Thymosin
Infectious Diseases
Hepadnaviridae
HBeAg
Immunology
DNA, Viral
Female
Drug Monitoring
business
Viral load
Peginterferon alfa-2a
medicine.drug
Subjects
Details
- ISSN :
- 10969071
- Volume :
- 83
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of medical virology
- Accession number :
- edsair.doi.dedup.....9b3671f794ec9c7d179636da432bcedd