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Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study
- Source :
- BJOG: An International Journal of Obstetrics & Gynaecology. 120:948-959
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- To investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome.Cohort study.Norwegian population.A total of 90 417 women and singleton child pairs.The Norwegian Mother and Child Cohort Study and Medical Birth Registry of Norway data sets were used.Infant survival, congenital malformations, structural heart defects, neonatal complications, haemorrhage during pregnancy and postpartum, asthma at age of 18 months.One or more of the four nonsteroidal anti-inflammatory drugs (NSAIDs) were used by 6511 pregnant women (7.2%). No effect on rates of infant survival, congenital malformation, or structural heart defects was found. The use of ibuprofen in the second trimester was significantly associated with low birthweight (adjusted OR 1.7, 95% CI 1.3-2.3), and ibuprofen use in the second and third trimesters was significantly associated with asthma in 18-month-old children (adjusted OR 1.5, 95% CI 1.2-1.9; adjusted OR 1.5, 95% CI 1.1-2.1). The use of diclofenac in the second trimester was significantly associated with low birthweight (adjusted OR 3.1, 95% CI 1.1-9.0), whereas diclofenac use in the third trimester was significantly associated with maternal vaginal bleeding (adjusted OR 1.8, 95% CI 1.1-3.0). No associations with other neonatal complications were found.The lack of associations with congenital malformations is reassuring. The significant association between diclofenac and ibuprofen use late in pregnancy, and maternal bleeding and asthma in the child, respectively, is consistent with their pharmacological effects. The increased risk of low birthweight may partly have been caused by underlying inflammatory conditions, and was reassuringly similar to the expected baseline risk of low birthweight.
- Subjects :
- Adult
Risk
medicine.medical_specialty
Naproxen
Diclofenac
genetic structures
Ibuprofen
Toxicology
Piroxicam
Cohort Studies
Young Adult
Pregnancy
Internal medicine
medicine
Humans
Prospective Studies
Prospective cohort study
Norway
Obstetrics
business.industry
organic chemicals
Anti-Inflammatory Agents, Non-Steroidal
Infant, Newborn
Pregnancy Outcome
Obstetrics and Gynecology
Infant, Low Birth Weight
medicine.disease
Pregnancy Complications
stomatognathic diseases
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14700328
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- BJOG: An International Journal of Obstetrics & Gynaecology
- Accession number :
- edsair.doi.dedup.....9b358c6a7d26e7e118623f4a5343862a