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Ki-67 and p53 expression of the fallopian tube mucosa in breast cancer patients with hereditary risk
- Source :
- Archives of Gynecology and Obstetrics. 289:1079-1085
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- The fallopian tube has been implicated as a site of origin of sporadic and BRCA1-related ovarian cancer. To investigate if Ki-67 or p53 is altered in BRCA1 mutation carriers, we have studied the expression of these markers in morphologically normal mucosa in the fallopian tube and fimbriae.Prophylactic adnexectomy specimens from 24 patients (eight BRCA1 mutation carriers, eight non-mutation carriers, and eight with unknown BRCA1 status), were scored by automated image analysis for the amount of Ki-67 and wild-type p53 expression. All patients had a history of breast cancer and a family history of breast or ovarian cancer.In the fimbriae, a median of 0.42 % Ki-67 and 0.04 % p53-positive epithelial cells was present, compared to a median of 0.36 % for Ki-67 and 0.05 % for p53 in the fallopian tube. Ki-67 expression decreased significantly with age (r = -0.45, p = 0.028). In contrast, p53 expression was not age-dependent for the whole group of patients (r = 0.25, p = 0.25). Subgroup analysis revealed a difference for p53 expression of the BRCA1 mutation carriers with respect to age (median 0.039 vs. 0.082 % for age less or greater than 50.5 years). Consequently, the p53/Ki-67 ratio showed an age-dependent increase, which was accelerated in the BRCA1-positive patients.Ki-67 and p53 expression varies in morphologically normal tubal epithelial cells depending on age and BRCA1 mutation status. This may reflect an altered and age-dependent DNA repair in BRCA1 mutation carriers and may be related to increased risk of ovarian cancer arising in the fallopian tube.
- Subjects :
- Adult
Risk
Oncology
Heterozygote
endocrine system
medicine.medical_specialty
Pathology
animal structures
endocrine system diseases
Fimbria
Genes, BRCA1
Breast Neoplasms
Ovarian carcinogenesis
Breast cancer
Internal medicine
Animals
Fallopian Tube Neoplasms
Humans
Medicine
Genetic Predisposition to Disease
skin and connective tissue diseases
P53 expression
Brca1 gene
Aged
Ovarian Neoplasms
Mucous Membrane
biology
business.industry
Age Factors
Obstetrics and Gynecology
General Medicine
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
Ki-67 Antigen
medicine.anatomical_structure
Socioeconomic Factors
Ki-67
Mutation
biology.protein
Female
Tumor Suppressor Protein p53
business
Ovarian cancer
Fallopian tube
Subjects
Details
- ISSN :
- 14320711 and 09320067
- Volume :
- 289
- Database :
- OpenAIRE
- Journal :
- Archives of Gynecology and Obstetrics
- Accession number :
- edsair.doi.dedup.....9b2547ab2f0fc4be4b5c0bb9f89450e1