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Gut microbiota disorders cause type 2 diabetes mellitus and homeostatic disturbances in gut-related metabolism in Japanese subjects

Authors :
Tomoya Sugiyama
Yasushi Funaki
Naotaka Ogasawara
Yoshiharu Yamaguchi
Kunio Kasugai
Chiho Goto
Kazunori Adachi
Masahide Ebi
Yasutaka Hijikata
Yasuhiro Tamura
Shinya Izawa
Makoto Sasaki
Source :
Journal of Clinical Biochemistry and Nutrition
Publication Year :
2019
Publisher :
The Society for Free Radical Research Japan, 2019.

Abstract

Few studies have investigated the host-microbe metabolic axis in people with type 2 diabetes mellitus (T2DM). This study aimed to determine and compare the nutrient intakes and metabolic markers and to elucidate the relationships among these factors in Japanese T2DM patients and control individuals. Fifty-nine Japanese T2DM patients and 59 matched healthy control individuals participated in this study. We examined the differences regarding the participants’ dietary habits, microbiota, and fecal short-chain fatty acids, and analyzed the relationships between the gut microbiota and blood metabolic markers in the T2DM patients and the control subjects. The T2DM patients consumed more carbohydrates, and had lower fecal propionate and butyrate concentrations, larger fecal populations of Bifidobacterium spp. and bacteria of the order Lactobacillales, and smaller fecal Bacteroides spp. populations than the control individuals. In the T2DM patients, the level of Bifidobacterium spp. correlated negatively with the carbohydrate intake and the level of bacteria of the order Lactobacillales correlated negatively with the protein intake. T2DM patients have gut dysbiosis that may contribute to disease onset and influence its prognosis. Furthermore, homeostatic disturbances in the gut-related metabolism may underlie the pathogenesis of T2DM.

Details

ISSN :
18805086 and 09120009
Volume :
64
Database :
OpenAIRE
Journal :
Journal of Clinical Biochemistry and Nutrition
Accession number :
edsair.doi.dedup.....9b23f23453a0644e02157112eb728302
Full Text :
https://doi.org/10.3164/jcbn.18-101