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Gut microbiota disorders cause type 2 diabetes mellitus and homeostatic disturbances in gut-related metabolism in Japanese subjects
- Source :
- Journal of Clinical Biochemistry and Nutrition
- Publication Year :
- 2019
- Publisher :
- The Society for Free Radical Research Japan, 2019.
-
Abstract
- Few studies have investigated the host-microbe metabolic axis in people with type 2 diabetes mellitus (T2DM). This study aimed to determine and compare the nutrient intakes and metabolic markers and to elucidate the relationships among these factors in Japanese T2DM patients and control individuals. Fifty-nine Japanese T2DM patients and 59 matched healthy control individuals participated in this study. We examined the differences regarding the participants’ dietary habits, microbiota, and fecal short-chain fatty acids, and analyzed the relationships between the gut microbiota and blood metabolic markers in the T2DM patients and the control subjects. The T2DM patients consumed more carbohydrates, and had lower fecal propionate and butyrate concentrations, larger fecal populations of Bifidobacterium spp. and bacteria of the order Lactobacillales, and smaller fecal Bacteroides spp. populations than the control individuals. In the T2DM patients, the level of Bifidobacterium spp. correlated negatively with the carbohydrate intake and the level of bacteria of the order Lactobacillales correlated negatively with the protein intake. T2DM patients have gut dysbiosis that may contribute to disease onset and influence its prognosis. Furthermore, homeostatic disturbances in the gut-related metabolism may underlie the pathogenesis of T2DM.
- Subjects :
- 0301 basic medicine
endocrine system diseases
Clinical Biochemistry
Medicine (miscellaneous)
Physiology
Butyrate
Type 2 diabetes
Gut flora
dietary habit
03 medical and health sciences
gut dysbiosis
fluids and secretions
0302 clinical medicine
Medicine
Feces
Bifidobacterium
030109 nutrition & dietetics
Nutrition and Dietetics
biology
business.industry
Short-chain fatty acid
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
biology.organism_classification
medicine.disease
Bifidobacterium spp
Original Article
030211 gastroenterology & hepatology
type 2 diabetes
Bacteroides
short-chain fatty acid
business
Subjects
Details
- ISSN :
- 18805086 and 09120009
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Biochemistry and Nutrition
- Accession number :
- edsair.doi.dedup.....9b23f23453a0644e02157112eb728302
- Full Text :
- https://doi.org/10.3164/jcbn.18-101