Food consumption increases cell proliferation in the python brain

Pythons are model organisms for investigating physiological responses to food intake. While systemic growth in response to food consumption is well documented, what occurs in the brain is currently unexplored. In this study, male ball pythons (Python regius) were used to test the hypothesis that food consumption stimulates cell proliferation in the brain. We used 5-bromo-12’-deoxyuridine as a cell-birth marker to quantify and compare cell proliferation in the brain of fasted snakes and those at two and six days after a meal. Throughout the telencephalon, cell proliferation was significantly increased in the six-day group, with no difference between the two-day group and controls. Systemic postprandial plasticity occurs quickly after a meal is ingested, during the period of active digestion; however, the brain displays a surge of cell proliferation after most digestion and absorption is complete.