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Association between circadian disruption and diseases: A narrative review
- Source :
- Life sciences. 262
- Publication Year :
- 2020
-
Abstract
- Circadian rhythms play an important role in a wide range of human physiology and pathology. Individuals increasingly experience situations such as night-shift work schedules, likely leading to circadian disruption. Recent studies have also demonstrated that patients with other diseases often show symptoms of circadian disruption as manifested by the sleep-wake cycle and other biological rhythms. Circadian disruption often results in changes to the phase, period, and amplitude of the sleep-wake cycle, melatonin rhythm, and core body temperature. Several cardiometabolic, psychiatric, and neurodegenerative diseases are closely related to circadian disruption. Several interventions are also available, including phototherapy, exogenous melatonin, and exercise. The cumulative findings suggest that circadian disruption can increase risk for some cardiometabolic diseases. Circadian disruption also acts as a concomitant symptom of several psychiatric and neurodegenerative diseases. More attention should be paid to evaluating the impact of circadian disruption on these related diseases, as well as the benefits of the mitigation interventions for both circadian disruption and related diseases.
- Subjects :
- 0301 basic medicine
Circadian disruption
Period (gene)
Melatonin rhythm
Bioinformatics
Chronobiology Disorders
030226 pharmacology & pharmacy
General Biochemistry, Genetics and Molecular Biology
Melatonin
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Circadian rhythm
General Pharmacology, Toxicology and Pharmaceutics
Exercise
Chronobiology
business.industry
General Medicine
Human physiology
Phototherapy
Circadian Rhythm
030104 developmental biology
Narrative review
business
medicine.drug
Subjects
Details
- ISSN :
- 18790631
- Volume :
- 262
- Database :
- OpenAIRE
- Journal :
- Life sciences
- Accession number :
- edsair.doi.dedup.....9b0a6ed78c8af3dfea597420591784b0