Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature

// Jaeyun Jung 1, * , Cue Hyunkyu Lee 3, * , Hyang Sook Seol 4 , Yeon Sook Choi 4 , Eunji Kim 3, 5 , Eun Ji Lee 1 , Je-Keun Rhee 6 , Shree Ram Singh 7 , Eun Sung Jun 1 , Buhm Han 3 , Seung Mo Hong 8 , Song Cheol Kim 9 , Suhwan Chang 1, 2 1 Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea 2 Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea 3 Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea 4 Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea 5 Department of Chemistry, Seoul National University, Seoul, Korea 6 Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea 7 Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA 8 Department of Pathology, Asan Medical Center, Seoul, Korea 9 Department of Surgery, Asan Medical Center, Seoul, Korea * These authors have contributed equally to this work Correspondence to: Song Cheol Kim, email: drksc@amc.seoul.kr Suhwan Chang, email: suhwan.chang@amc.seoul.kr Keywords: pancreatic cancer, patient-derived xenograft, single nucleotide polymorphism, cancer panel, heterogeneity Received: June 01, 2016 Accepted: August 08, 2016 Published: August 23, 2016 ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is the most challenging type of cancer to treat, with a 5-year survival rate of