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Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study

Authors :
Ophir Gilad
Guy Rosner
Dana Ivancovsky-Wajcman
Reut Zur
Rina Rosin-Arbesfeld
Nathan Gluck
Hana Strul
Dana Lehavi
Vivien Rolfe
Revital Kariv
Source :
Genes; Volume 13; Issue 12; Pages: 2182
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Several studies have demonstrated that curcumin can cause the regression of polyps in familial adenomatous polyposis (FAP), while others have shown negative results. Wholistic turmeric (WT) containing curcumin and additional bioactive compounds may contribute to this effect. We performed a double-blinded, randomized, controlled trial to assess the efficacy of WT in FAP patients. Ten FAP patients were randomly assigned to receive either WT or placebo for 6 months. Colonoscopies were performed at baseline and after 6 months. The polyp number and size, as well as the cumulative polyp burden, were assessed. No differences were noted between the groups in terms of changes from the baseline’s polyp number, size, or burden. However, stratifying the data according to the right vs. left colon indicated a decrease in the median polyp number (from 5.5 to 1.5, p = 0.06) and polyp burden (from 24.25 mm to 11.5 mm, p = 0.028) in the left colon of the patients in the WT group. The adjusted left polyp number and burden in the WT arm were lower by 5.39 (p = 0.034) and 14.68 mm (p = 0.059), respectively. Whether WT can be used to reduce the polyp burden of patients with predominantly left-sided polyps remains to be seen; thus, further larger prospective trials are required.

Details

ISSN :
20734425
Volume :
13
Database :
OpenAIRE
Journal :
Genes
Accession number :
edsair.doi.dedup.....9affc50122f6b24f026836066dd45eec
Full Text :
https://doi.org/10.3390/genes13122182