Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy

Yamamoto highlights work from Nthiga et al. that shows that Calcoco1 binds Golgi-resident ZDHHC17 to facilitate autophagic degradation of the Golgi.
Degradation by macroautophagy can be highly selective, but given the promiscuity of cargo receptors, questions remain surrounding how this selectivity is achieved. In this issue, Nthiga et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202006128) show how the adaptor Calcoco1 distinguishes cargo by how it binds.