Back to Search
Start Over
PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: A expression patterns and clinical implications
- Source :
- Human Pathology, 81, pp. 157-165, Human Pathology, 81, 157-165, Human Pathology, 81, 157. W.B. Saunders Ltd
- Publication Year :
- 2018
-
Abstract
- Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC), a variant of pancreatic ductal adenocarcinoma (PDAC), has a striking genetic similarity to PDAC but a significantly improved overall survival. We hypothesize that this difference could be due to the immune response to the tumor, and as such, we investigated the expression of PD-1, PD-L1, and CD163 in a series of UCOGC. To this aim, 27 pancreatic UCOGCs (11 pure and 16 PDAC-associated), 5 extrapancreatic tumors with osteoclast-like giant cells and 10 pancreatic anaplastic carcinomas were immunostained using antibodies against PD-1, PD-L1, and CD163. In pancreatic UCOGCs, PD-L1 was expressed in neoplastic cells of 17 (63%) of 27 cases, more often in cases with an associated PDAC (P =.04). Expression of PD-L1 was associated with poor prognosis, confirmed by multivariate analysis: patients with PD-L1–positive UCOGCs had a risk of all-cause mortality that was 3 times higher than did patients with PD-L1–negative UCOGCs (hazard ratio, 3.397; 95% confidence interval, 1.023-18.375; P =.034). PD-L1 expression on tumor cells was also associated with aberrant P53 expression (P =.035). PD-1 was expressed on rare lymphocytes in 12 UCOGCs (44.4%), mainly located at the tumor periphery. CD163 was expressed on histiocytes, with a diffuse and strong staining pattern in all UCOGCs. Extrapancreatic tumors with osteoclast-like giant cells showed very similar staining patterns for the same proteins. Anaplastic carcinomas have some similarities to UCOGCs, but PD-L1 has no prognostic roles. Our results may have important implications for immunotherapeutic strategies in UCOGCs; these tumors may also represent a model for future therapeutic approaches against PDAC. © 2018 Elsevier Inc.
- Subjects :
- Male
0301 basic medicine
Indiana
Programmed Cell Death 1 Receptor
Osteoclast
PDAC
Pancreatic Cancer
Tumor-Associated Macrophages
UCOGC
Osteoclasts
Giant Cells
B7-H1 Antigen
0302 clinical medicine
Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14]
Lymphocytes
Aged, 80 and over
biology
Tumor-associated macrophages
Cell Differentiation
Middle Aged
Pancreatic cancer
2734
Immunohistochemistry
Europe
Phenotype
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Antibody
Carcinoma, Pancreatic Ductal
Adult
Antigens, Differentiation, Myelomonocytic
Receptors, Cell Surface
Pathology and Forensic Medicine
03 medical and health sciences
Immune system
All institutes and research themes of the Radboud University Medical Center
Antigens, CD
PD-L1
Biomarkers, Tumor
medicine
Humans
Histiocyte
Aged
Neoplasm Staging
Histiocytes
medicine.disease
Pancreatic Neoplasms
030104 developmental biology
Giant cell
Cancer research
biology.protein
CD163
Subjects
Details
- ISSN :
- 00468177
- Database :
- OpenAIRE
- Journal :
- Human Pathology, 81, pp. 157-165, Human Pathology, 81, 157-165, Human Pathology, 81, 157. W.B. Saunders Ltd
- Accession number :
- edsair.doi.dedup.....9ae7c9526a2455e0983b64601e591720