Back to Search
Start Over
New phenylpropanoids from the fruits of Xanthium sibiricum and their anti-inflammatory activity
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis, 2020.
-
Abstract
- Seven new phenylpropanoids, including two pairs of enantiomers of 8-O-4′-type neolignans, named (±)-xanthiifructins A-B (1a/1b-2a/2b), a pair of simple phenylpropanoid derivatives (±)-xanthiifructins C (3a/3b), and a racemic phenylpropanoid derivative xanthiifructin D (4), together with four known analogues (5-8) were isolated from the fruits of Xanthium sibiricum. Racemic xanthiifructins A-C were separated on chiral HPLC columns. Their structures were elucidated by comprehensive spectroscopic data analysis and comparison with the literatures. The anti-inflammatory and cytotoxic activities were evaluated for all isolates. Among them, (-)-xanthiifructin C (3b) exhibited potent inhibitory effect against nitric oxide production in lipopolysaccharide-activated RAW 264.7 mouse macrophage cells with an IC50 value of 9.94 ± 0.57 μM. All compounds obviously were inactive for three human tumor cell lines (MCF-7, HepG2, and A549) with IC50 values much more than 10 μM.
- Subjects :
- Phenylpropanoid
010405 organic chemistry
medicine.drug_class
Stereochemistry
Chemistry
Organic Chemistry
Plant Science
01 natural sciences
Biochemistry
Anti-inflammatory
0104 chemical sciences
Analytical Chemistry
Xanthium sibiricum
010404 medicinal & biomolecular chemistry
medicine
Enantiomer
Cytotoxicity
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9ad477ceda15856e26e837e7c3d341b7
- Full Text :
- https://doi.org/10.6084/m9.figshare.12849350.v1