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Effects of dietary intake and nutritional status on cerebral oxygenation in patients with chronic kidney disease not undergoing dialysis: A cross-sectional study
- Source :
- PLoS ONE, Vol 14, Iss 10, p e0223605 (2019), PLoS ONE
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- BackgroundDietary management is highly important for the maintenance of renal function in patients with chronic kidney disease (CKD). Cerebral oxygen saturation (rSO2) was reportedly associated with the estimated glomerular filtration rate (eGFR) and cognitive function. However, data concerning the association between cerebral rSO2 and dietary intake of CKD patients is limited.MethodsThis was a single-center observational study. We recruited 67 CKD patients not undergoing dialysis. Cerebral rSO2 was monitored using the INVOS 5100c oxygen saturation monitor. Energy intake was evaluated by dietitians based on 3-day meal records. Daily protein and salt intakes were calculated from 24-h urine collection.ResultsMultivariable regression analysis showed that cerebral rSO2 was independently associated with energy intake (standardized coefficient: 0.370) and serum albumin concentration (standardized coefficient: 0.236) in Model 1 using parameters with p < 0.10 in simple linear regression analysis (body mass index, Hb level, serum albumin concentration, salt and energy intake) and confounding factors (eGFR, serum sodium concentration, protein intake), and the energy/salt index (standardized coefficient: 0.343) and Hb level (standardized coefficient: 0.284) in Model 2 using energy/protein index as indicated by energy intake/protein intake and energy/salt index by energy intake/salt intake in place of salt, protein and energy intake.ConclusionsCerebral rSO2 is affected by energy intake, energy/salt index, serum albumin concentration and Hb level. Sufficient energy intake and adequate salt restriction is important to prevent deterioration of cerebral oxygenation, which might contribute to the maintenance of cognitive function in addition to the prevention of renal dysfunction in CKD patients.
- Subjects :
- Male
Serum Proteins
Physiology
medicine.medical_treatment
030232 urology & nephrology
Sodium Chloride
Urine
030204 cardiovascular system & hematology
Biochemistry
Gastroenterology
Mathematical and Statistical Techniques
0302 clinical medicine
Blood serum
Chronic Kidney Disease
Medicine and Health Sciences
Multidisciplinary
biology
Statistics
Brain
Body Fluids
Chemistry
Nephrology
Physical Sciences
Regression Analysis
Medicine
Female
Anatomy
Research Article
Chemical Elements
medicine.medical_specialty
Science
Serum albumin
Nutritional Status
Renal function
Linear Regression Analysis
Research and Analysis Methods
03 medical and health sciences
Renal Dialysis
Albumins
Internal medicine
medicine
Humans
Renal Insufficiency, Chronic
Statistical Methods
Salt intake
Serum Albumin
Dialysis
Aged
business.industry
Chemical Compounds
Dietary management
Biology and Life Sciences
Proteins
Renal System
medicine.disease
Diet
Oxygen
Cross-Sectional Studies
Multivariate Analysis
Linear Models
biology.protein
Salts
Energy Intake
business
Body mass index
Mathematics
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....9ad23aa16c3e429c2af1567f09992603