Adducin in tumorigenesis and metastasis

// Cong Luo 1 and Jiayu Shen 2 1 Zhejiang Cancer Hospital, Department of Abdominal oncology, Hangzhou, Zhejiang, China 2 Zhejiang Chinese Medical University, The Second Clinical Medical College, Hangzhou, Zhejiang, China Correspondence to: Cong Luo, email: CongLuo939291@gmail.com Keywords: adducin, phosphorylation, tumor Received: November 16, 2016 Accepted: March 28, 2017 Published: April 18, 2017 ABSTRACT Adducin is a membrane-skeletal protein localized at spectrin-actin junctions, involving in the formation of the network of cytoskeleton, cellular signal transduction, ionic transportation, cell motility and cell proliferation. While previous researches focused mainly on the relationship between adducin and hypertension, there are few studies focusing on the role of adducin in tumor. Previous studies showed that adducin played a role in the evolution and progression of neoplasm. This review makes a brief summary on the structure, function and mechanism of adducin and how adducin functions in tumorigenesis and metastasis.