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Clinical Relevance of Serum Interleukin-6 in Crohn's Disease: Single Point Measurements, Therapy Monitoring, and Prediction of Clinical Relapse
- Source :
- American Journal of Gastroenterology. 94:2156-2164
- Publication Year :
- 1999
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1999.
-
Abstract
- To investigate the clinical relevance of interleukin-6 (IL-6) serum levels in patients with Crohn's disease (CD), single point IL-6 measurements in sera from consecutive CD patients and healthy donors (HD), as well as longitudinal measurements during the course of steroid therapy for active CD were performed. Patients with steroid-induced remission were followed until clinical relapse.One hundred thirty-six CD patients without steroid or other immunosuppressive treatment within 2 months and surgical procedures within 3 months before study entry were investigated; 63 patients with active CD were enrolled into the follow-up program. Clinical activity was evaluated by the Crohn's disease activity index (CDAI) and serum IL-6 levels measured by enzyme-linked immunosorbent assay.IL-6 serum levels were significantly elevated in CD patients compared to HD (p0.001). In individual patients serum IL-6 levels correlated with corresponding CDAI scores in a subgroup referred to as primarily inflammatory patients presenting without bowel stenosis, previous intestinal resection, or concomitant inflammatory disorders (r = 0.72, p0.001). Primarily inflammatory patients displayed higher serum IL-6 levels (median: 6.0 pg/ml; range: 1.3-25) than CD patients with bowel stenosis (median: 2.0; range: 1.3-4.9; p0.01) or extensive intestinal resection (median: 1.5; range: 1.3-13.7; p0.001). Longitudinally measured serum IL-6 levels reflected the clinical response during steroid therapy and predicted clinical relapse after steroid-induced remission at week 9 of the treatment protocol.Serum IL-6 is a clinically relevant parameter for CD that correlates with inflammatory activity and implies a prognostic value after steroid-induced remission.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Prednisolone
Anti-Inflammatory Agents
Enzyme-Linked Immunosorbent Assay
Disease
Drug Administration Schedule
Crohn Disease
Recurrence
Internal medicine
Humans
Medicine
Clinical significance
Interleukin 6
Crohn's disease
Dose-Response Relationship, Drug
Hepatology
biology
Interleukin-6
business.industry
Crohn disease
Gastroenterology
Follow up studies
Middle Aged
medicine.disease
digestive system diseases
Treatment Outcome
Immunology
biology.protein
Female
Therapy monitoring
Single point
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029270
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- American Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....9aa9d58a87869799fabcaf301ef2a418