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Intertumoral Heterogeneity within Medulloblastoma Subgroups
- Source :
- Cancer Cell, 31(6), 737-+. Cell Press, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Cancer Cell, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, Cancer cell, vol 31, iss 6, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname
- Publication Year :
- 2017
-
Abstract
- While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
- Subjects :
- 0301 basic medicine
Cancer Research
medulloblastoma
CURRENT CONSENSUS
copy number
Bioinformatics
subgroups
Cohort Studies
Individual data
Cluster Analysis
R PACKAGE
Precision Medicine
GENECHIP DATA
Sonic hedgehog
ADULT MEDULLOBLASTOMA
DNA Copy Number Variation
Cancer
Pediatric
Genomics
methylation
CANCER
3. Good health
Oncology
DNA methylation
Human
Pediatric Research Initiative
DNA Copy Number Variations
Pediatric Cancer
Oncology and Carcinogenesis
Computational biology
Biology
Article
CLASSIFICATION
Homogeneous clusters
03 medical and health sciences
Rare Diseases
Genetics
medicine
Humans
Oncology & Carcinogenesis
Cerebellar Neoplasms
RECURRENCE
neoplasms
Medulloblastoma
Cluster Analysi
gene expression
MUTATIONS
subgroup
Gene Expression Profiling
Human Genome
Neurosciences
integrative clustering
DNA Methylation
medicine.disease
Precision medicine
MEDULOBLASTOMA
Brain Disorders
nervous system diseases
Brain Cancer
Gene expression profiling
stomatognathic diseases
030104 developmental biology
Genomic
biology.protein
MOLECULAR SUBGROUPS
GENOMIC DATA
Cohort Studie
Subjects
Details
- ISSN :
- 15356108
- Database :
- OpenAIRE
- Journal :
- Cancer Cell, 31(6), 737-+. Cell Press, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Cancer Cell, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, Cancer cell, vol 31, iss 6, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname
- Accession number :
- edsair.doi.dedup.....9a9fff537515fd4a151593b469adea0d