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Programmable Paper-Based Microfluidic Devices for Biomarker Detections
- Source :
- Micromachines, Micromachines, Vol 10, Iss 8, p 516 (2019)
- Publication Year :
- 2019
-
Abstract
- Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development.
- Subjects :
- Computer science
lcsh:Mechanical engineering and machinery
Microfluidics
02 engineering and technology
Review
01 natural sciences
Hardware_INTEGRATEDCIRCUITS
digital microfluidic device
lcsh:TJ1-1570
Electrical and Electronic Engineering
Hardware_ARITHMETICANDLOGICSTRUCTURES
biomarker detection
paper-based microfluidic device
business.industry
Mechanical Engineering
010401 analytical chemistry
Paper based
droplet actuation
021001 nanoscience & nanotechnology
Automation
flow control
0104 chemical sciences
multi-step assay
Flow control (fluid)
Control and Systems Engineering
Embedded system
Biomarker (medicine)
0210 nano-technology
business
Subjects
Details
- ISSN :
- 2072666X
- Volume :
- 10
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Micromachines
- Accession number :
- edsair.doi.dedup.....9a91dd3f0ef5224520a3593746d9659d