Back to Search
Start Over
Bioactive chitosan-based scaffolds with improved properties induced by dextran-grafted nano-maghemite and l-arginine amino acid
- Source :
- Journal of biomedical materials research. Part A 107 (2019): 1244–1252. doi:10.1002/jbm.a.36633, info:cnr-pdr/source/autori:Scialla S.; Barca A.; Palazzo B.; D'Amora U.; Russo T.; Gloria A.; De Santis R.; Verri T.; Sannino A.; Ambrosio L.; Gervaso F./titolo:Bioactive chitosan-based scaffolds with improved properties induced by dextran-grafted nano-maghemite and l-arginine amino acid/doi:10.1002%2Fjbm.a.36633/rivista:Journal of biomedical materials research. Part A/anno:2019/pagina_da:1244/pagina_a:1252/intervallo_pagine:1244–1252/volume:107
- Publication Year :
- 2019
-
Abstract
- Over the past years, fundamentals of magnetism opened a wide research area of interest, in the field of tissue engineering and regenerative medicine. The integration of magnetic nanoarchitectures into synthetic/natural scaffold formulations allowed obtaining "on demand" responsive structures able to guide the regeneration process. The aim of this work was the design and characterization of three-dimensional (3D) chitosan-based scaffolds containing dextran-grafted maghemite nanoarchitectures (DM) and functionalized with l-arginine (l-Arg) amino acid as bioactive agent. A homogeneous pore distribution and a high degree of interconnection were obtained for all the structures with DMs, which resulted well distributed inside the polymer matrix. All the results suggest that the simultaneous presence of DMs and l-Arg conferred interesting mechano-structural and bioactive properties toward osteoblast-like and human mesenchymal stem cells, differentially stimulating their proliferation both in the absence and in the presence of a time-dependent magnetic field. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1244-1252, 2019.
- Subjects :
- Scaffold
Materials science
0206 medical engineering
Biomedical Engineering
Maghemite
L-arginine
Ceramics and Composite
02 engineering and technology
engineering.material
Matrix (biology)
Arginine
Biomaterials
Chitosan
chemistry.chemical_compound
Tissue engineering
Cell Line, Tumor
Humans
Magnetite Nanoparticles
chemistry.chemical_classification
Osteoblasts
Tissue Scaffolds
Metals and Alloys
Dextrans
Mesenchymal Stem Cells
Polymer
021001 nanoscience & nanotechnology
020601 biomedical engineering
Biomaterial
Amino acid
Dextran
chemistry
Chemical engineering
Ceramics and Composites
engineering
chitosan
magnetic scaffold
0210 nano-technology
magnetic nanoarchitecture
Subjects
Details
- Language :
- English
- ISSN :
- 12441252
- Database :
- OpenAIRE
- Journal :
- Journal of biomedical materials research. Part A 107 (2019): 1244–1252. doi:10.1002/jbm.a.36633, info:cnr-pdr/source/autori:Scialla S.; Barca A.; Palazzo B.; D'Amora U.; Russo T.; Gloria A.; De Santis R.; Verri T.; Sannino A.; Ambrosio L.; Gervaso F./titolo:Bioactive chitosan-based scaffolds with improved properties induced by dextran-grafted nano-maghemite and l-arginine amino acid/doi:10.1002%2Fjbm.a.36633/rivista:Journal of biomedical materials research. Part A/anno:2019/pagina_da:1244/pagina_a:1252/intervallo_pagine:1244–1252/volume:107
- Accession number :
- edsair.doi.dedup.....9a877c350f96d378d80092cdbcb995a3