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Effect of sugar and monoglyceride on fatty acid esterification
- Source :
- American Journal of Physiology-Endocrinology and Metabolism. 234:E236
- Publication Year :
- 1978
- Publisher :
- American Physiological Society, 1978.
-
Abstract
- The effect of hexose and monoolein on fatty acid esterification was studied in everted rings of rat jejunum. By use of [3H]oleic acid and [U-14C]glucose, esterification via both phosphatidic acid and monoglyceride pathways was quantified. Our results showed that 1) metabolizable sugars stimulate fatty acids esterification regardless of their mode of transport; 2) in the presence of glucose alone, in vitro fatty acid esterification is mediated entirely by the phosphatidic acid pathway; 3) glucose stimulates both esterification pathways in the presence of monoolein; 4) monoolein stimulates only the monoglyceride pathway and has no effect on the phosphatidic acid pathway; and 5) the rate-limiting factor in the presence of monoolein alone is the formation of acyl-CoA, whereas in the presence of glucose alone, the rate-limiting factor is the formation of alpha-glycerophosphate.
- Subjects :
- Male
Physiology
Endocrinology, Diabetes and Metabolism
Phosphatidic Acids
Oleic Acids
Fructose
chemistry.chemical_compound
Physiology (medical)
Animals
Hexose
Sugar
Rat Jejunum
Triglycerides
Hexoses
chemistry.chemical_classification
Esterification
Fatty Acids
Fatty acid
Phosphatidic acid
Monoglyceride
In vitro
Rats
Oleic acid
Glucose
chemistry
Biochemistry
Acyl Coenzyme A
Subjects
Details
- ISSN :
- 15221555 and 01931849
- Volume :
- 234
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....9a7c3c954f7feb8849d540ef5d46a695