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Polymer gel dosimetry for synchrotron stereotactic radiotherapy and iodine dose-enhancement measurements
- Source :
- Physics in Medicine and Biology, Physics in Medicine and Biology, IOP Publishing, 2007, 52 (16), pp.4881-92. ⟨10.1088/0031-9155/52/16/011⟩
- Publication Year :
- 2007
-
Abstract
- International audience; Synchrotron stereotactic radiotherapy (SSR) is a radiotherapy technique that makes use of the interactions of monochromatic low energy x-rays with high atomic number (Z) elements. An important dose-enhancement can be obtained if the target volume has been loaded with a sufficient amount of a high-Z element, such as iodine. In this study, we compare experimental dose measurements, obtained with normoxic polymer gel (nPAG), with Monte Carlo computations. Gels were irradiated within an anthropomorphic head phantom and were read out by magnetic resonance imaging. The dose-enhancement due to the presence of iodine in the gel (iodine concentration: 5 and 10 mg ml(-1)) was measured at two radiation energies (35 and 80 keV) and was compared to the calculated factors. nPAG dosimetry was shown to be efficient for measuring the sharp dose gradients produced by SSR. The agreement between 3D gel dosimetry and calculated dose distributions was found to be within 4% of the dose difference criterion and a distance to agreement of 2.1 mm for 80% of the voxels. Polymer gel doped with iodine exhibited higher sensitivity, in good agreement with the calculated iodine-dose enhancement. We demonstrate in this preliminary study that iodine-doped nPAG could be used for measuring in situ dose distributions for iodine-enhanced SSR treatment.
- Subjects :
- Materials science
MESH: Iodine
Polymers
MESH: Gels
chemistry.chemical_element
Dose profile
Radiation
Gel dosimetry
Iodine
Radiosurgery
Sensitivity and Specificity
Imaging phantom
030218 nuclear medicine & medical imaging
law.invention
03 medical and health sciences
0302 clinical medicine
law
MESH: Radiosurgery
MESH: Dose-Response Relationship, Radiation
Dosimetry
Radiology, Nuclear Medicine and imaging
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Irradiation
MESH: Radiotherapy Dosage
Radiometry
Radiological and Ultrasound Technology
business.industry
Radiochemistry
MESH: Radiometry
Reproducibility of Results
Dose-Response Relationship, Radiation
Radiotherapy Dosage
Synchrotron
MESH: Sensitivity and Specificity
MESH: Polymers
MESH: Reproducibility of Results
chemistry
030220 oncology & carcinogenesis
MESH: Synchrotrons
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Nuclear medicine
business
Gels
Synchrotrons
Subjects
Details
- ISSN :
- 00319155 and 13616560
- Volume :
- 52
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Physics in medicine and biology
- Accession number :
- edsair.doi.dedup.....9a7a78e87769ed6c13b91e932ccf8e93