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Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad
- Source :
- Science Advances, Science Advances, American Association for the Advancement of Science (AAAS), 2022, 8 (21), ⟨10.1126/sciadv.abm0972⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, specification and subsequent sex-specific differentiation of a previously uncharacterized population of supporting-like cells (SLC) in the developing mouse gonads. The SLC lineage is closely related to the coelomic epithelium and specified as early as E10.5, making it the first somatic lineage to be specified in the bipotential gonad. SLC progenitors are localized within the genital ridge at the interface with the mesonephros and initially co-express Wnt4 and Sox9. SLCs become sexually dimorphic around E12.5, progressively acquire a Sertoli- or granulosa-like identity and contribute to the formation of the rete testis and rete ovarii. Finally, we found that WNT4 is a crucial regulator of the SLC lineage and is required for the formation of the rete testis.TeaserDescription of an uncharacterized multipotent gonadal cell lineage involved in testis and ovary development
- Subjects :
- 0303 health sciences
education.field_of_study
endocrine system
Gonad
Lineage (genetic)
Gonadal ridge
Mesonephros
[SDV]Life Sciences [q-bio]
Population
Biology
Coelomic epithelium
Cell biology
Rete ovarii
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Rete testis
medicine
education
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Database :
- OpenAIRE
- Journal :
- Science Advances, Science Advances, American Association for the Advancement of Science (AAAS), 2022, 8 (21), ⟨10.1126/sciadv.abm0972⟩
- Accession number :
- edsair.doi.dedup.....9a6e15a3a3a4d77a50543cd79afaaad0