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Prolonged Replication of a Type 1 Vaccine-Derived Poliovirus in an Immunodeficient Patient
- Source :
- Journal of Clinical Microbiology. 36:2893-2899
- Publication Year :
- 1998
- Publisher :
- American Society for Microbiology, 1998.
-
Abstract
- VP1 sequences were determined for poliovirus type 1 isolates obtained over a 189-day period from a poliomyelitis patient with common variable immunodeficiency syndrome (a defect in antibody formation). The isolate from the first sample, taken 11 days after onset of paralysis, contained two poliovirus populations, differing from the Sabin 1 vaccine strain by ∼10%, differing from diverse type 1 wild polioviruses by 19 to 24%, and differing from each other by 5.5% of nucleotides. Specimens taken after day 11 appeared to contain only one major poliovirus population. Evolution of VP1 sequences at synonymous third-codon positions occurred at an overall rate of ∼3.4% per year over the 189-day period. Assuming this rate to be constant throughout the period of infection, the infection was calculated to have started ∼9.3 years earlier. This estimate is about the time (6.9 years earlier) the patient received his last oral poliovirus vaccine dose, approximately 2 years before the diagnosis of immunodeficiency. These findings may have important implications for the strategy to eliminate poliovirus immunization after global polio eradication.
- Subjects :
- Adult
Male
Microbiology (medical)
viruses
Molecular Sequence Data
Population
Viral Plaque Assay
Biology
Virus Replication
medicine.disease_cause
complex mixtures
Polymerase Chain Reaction
Virus
Evolution, Molecular
Feces
Capsid
Virology
Poliomyelitis eradication
medicine
Paralysis
Humans
Amino Acid Sequence
Child
education
Phylogeny
Immunodeficiency
education.field_of_study
Base Sequence
Sequence Homology, Amino Acid
Poliovirus
Immunologic Deficiency Syndromes
Genetic Variation
medicine.disease
Poliomyelitis
Poliovirus Vaccine, Oral
Immunology
RNA, Viral
Enterovirus
Capsid Proteins
medicine.symptom
Sequence Alignment
Follow-Up Studies
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....9a6c272c675f40746203c3d481c1f4dd