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Influence of weight management on the prognosis of steatohepatitis in chronic hepatitis B patients during antiviral treatment
- Source :
- Hepatobiliary & Pancreatic Diseases International. 20:416-425
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Although concomitant nonalcoholic steatohepatitis (NASH) is common in chronic hepatitis B (CHB), the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear. We aimed to investigate the outcomes of NASH in CHB patients receiving antiviral treatment.In the post-hoc analysis of a multicenter trial, naïve CHB patients receiving 72-week entecavir treatment were enrolled. We evaluated the biochemical, viral and histopathological responses of these patients. The histopathological features of NASH were also evaluated, using paired liver biopsies at baseline and week 72.A total of 1000 CHB patients were finally enrolled for analysis, with 18.2% of whom fulfilling the criteria of NASH. A total of 727 patients completed entecavir antiviral treatment and received the second biopsy. Serum HBeAg loss, HBeAg seroconversion and HBV-DNA undetectable rates were similar between patients with or without NASH (P0.05). Among patients with NASH, the hepatic steatosis, ballooning, lobular inflammation scores and fibrosis stages all improved during follow-up (all P0.001), 46% (63/136) achieved NASH resolution. Patients with baseline body mass index (BMI) ≥ 23 kg/mLower BMI and weight reduction but not virologic factors determine NASH resolution in CHB. The value of weight management in CHB patients during antiviral treatment deserves further evaluation.
- Subjects :
- Hepatitis B virus
medicine.medical_specialty
Weight Gain
Antiviral Agents
digestive system
Gastroenterology
Hepatitis B, Chronic
Non-alcoholic Fatty Liver Disease
Multicenter trial
Internal medicine
Biopsy
Humans
Medicine
Hepatitis B e Antigens
Hepatology
medicine.diagnostic_test
business.industry
nutritional and metabolic diseases
Entecavir
Hepatitis B
Prognosis
medicine.disease
digestive system diseases
Treatment Outcome
HBeAg
Concomitant
DNA, Viral
Steatosis
Steatohepatitis
business
medicine.drug
Subjects
Details
- ISSN :
- 14993872
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Hepatobiliary & Pancreatic Diseases International
- Accession number :
- edsair.doi.dedup.....9a68584ee05b529e1817b9e1a9151fe0