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Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts

Authors :
Johannes A. Sake
Johanna J. Salomon
Carsten Ehrhardt
Mohammed Ali Selo
Source :
International Journal of Molecular Sciences, Vol 21, Iss 9168, p 9168 (2020), International Journal of Molecular Sciences
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the transport of xenobiotics across various biological barriers, for example biguanides and histamine receptor antagonists. In addition, several drugs used in the treatment of respiratory disorders are cations at physiological pH and potential substrates of OCT/Ns. OCT/Ns may also be associated with the development of chronic lung diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD) and, thus, are possible new drug targets. As part of the Special Issue “Physiology, Biochemistry and Pharmacology of Transporters for Organic Cations”, this review provides an overview of recent findings on the (patho)physiological and pharmacological functions of organic cation transporters in the lung.

Details

Language :
English
ISSN :
16616596 and 14220067
Volume :
21
Issue :
9168
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....9a61a64217e4a8e1dda95aa771c8054a