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Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients
- Source :
- European psychiatry : the journal of the Association of European Psychiatrists. 24(7)
- Publication Year :
- 2009
-
Abstract
- Interest exists in identifying the factors that specifically contribute to the increased prevalence of cardiovascular disease observed in psychiatric disease. The apolipoprotein-E (APOE) gene codes for a protein that has a key role in metabolism of cholesterol and triglycerides, with increased levels of apoE found in specific areas of post-mortem schizophrenic brains. This study investigated whether apoE variants influence the prevalence of cardiovascular risk factors (obesity, diabetes and dyslipidaemia), in patients receiving antipsychotic treatment, due to extension of the risk seen in the general population, but also due to the role of the APOE gene in mediating antipsychotic-induced side effects. Seven polymorphisms (rs741780, rs483082, rs429358, rs7412, rs10119, rs439401 and rs405509) were genotyped in 427 American Caucasian patients who were either receiving, or had been prescribed risperidone. Our results support the hypothesis that APOE gene variants influence the prevalence of diabetes and possibly overweight in psychiatric patients. Unfortunately, due to the cross sectional nature of this study, the contribution of antipsychotic treatment was not determined. These associations warrant prospective study to assess interaction between APOE gene variants and the propensity of antipsychotics to induce cardiovascular risk factors.
- Subjects :
- Apolipoprotein E
medicine.medical_specialty
Genotype
medicine.drug_class
medicine.medical_treatment
Population
Hypercholesterolemia
Atypical antipsychotic
Hyperlipidemias
Disease
Bioinformatics
Polymorphism, Single Nucleotide
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Apolipoproteins E
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Obesity
Risk factor
Antipsychotic
education
Alleles
education.field_of_study
Risperidone
Polymorphism, Genetic
business.industry
Genetic Carrier Screening
Homozygote
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Endocrinology
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Hypertension
Schizophrenia
lipids (amino acids, peptides, and proteins)
business
030217 neurology & neurosurgery
medicine.drug
Antipsychotic Agents
Subjects
Details
- ISSN :
- 09249338
- Volume :
- 24
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- European psychiatry : the journal of the Association of European Psychiatrists
- Accession number :
- edsair.doi.dedup.....9a5dad085d0ce6b436a15bca87ae728c