Back to Search
Start Over
Registration on the Renal Transplantation Waiting List and Mortality on Dialysis: an Analysis of the French REIN Registry Using a Multi-state Model
- Source :
- Journal of Epidemiology, Journal of Epidemiology, Japan Epidemiological Association, 2015, 25 (2), pp.133-141. ⟨10.2188/jea.JE20130193⟩, Journal of Epidemiology, 2015, 25 (2), pp.133-141. ⟨10.2188/jea.JE20130193⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; AbstractBackground: Access to the renal transplantation (RT) waiting list depends on factors related to lower mortality rates and often occurs after dialysis initiation. The aim of the study was to use a flexible regression model to determine if registration on the RT waiting list is associated with mortality on dialysis, independent of the comorbidities associated with such registration.Methods: Data from the French REIN registry on 7138 incident hemodialysis (HD) patients were analyzed. A multi-state model including four states (‘HD, not wait-listed’, ‘HD, wait-listed’, ‘death’, and ‘RT’) was used to estimate the effect of being wait-listed on the probability of death.Results: During the study, 1392 (19.5%) patients were wait-listed. Of the 2954 deaths observed in the entire cohort during follow-up, 2921 (98.9%) were observed in the not wait-listed group compared with only 33 (1.1%) in the wait-listed group. In the multivariable analysis, the adjusted hazard ratio for death associated with non-registration on the waiting list was 3.52 (95% CI, 1.70–7.30). The risk factors for death identified for not wait-listed patients were not found to be significant risk factors for wait-listed patients, with the exception of age.Conclusions: The use of a multi-state model allowed a flexible analysis of mortality on dialysis. Patients who were not wait-listed had a much higher risk of death, regardless of co-morbidities associated with being wait-listed, and did not share the same risk factors of death as wait-listed patients. Registration on the waiting list should therefore be taken into account in survival analysis of patients on dialysis.
- Subjects :
- Male
Pediatrics
Epidemiology
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
MESH: Registries
030232 urology & nephrology
MESH: waiting list
MESH: Comorbidity
Comorbidity
01 natural sciences
MESH: Regression Analysis
MESH: Renal Dialysis/mortality
010104 statistics & probability
0302 clinical medicine
Risk Factors
MESH: Risk Factors
MESH: Models
Clinical Epidemiology
Registries
Kidney transplantation
MESH: Waiting Lists
MESH: Aged
MESH: Middle Aged
MESH: France/epidemiology
MESH: kidney transplantation
Hazard ratio
General Medicine
MESH: Follow-Up Studies
waiting list
Middle Aged
3. Good health
MESH: Survival Analysis
Cohort
Regression Analysis
MESH: renal dialysis
Original Article
Female
France
Hemodialysis
medicine.medical_specialty
Waiting Lists
Mesh:Female
Mesh:Comorbidity
Mesh:Follow-Up Studies
Mesh:France/epidemiology
Mesh:Humans
Mesh:Kidney Transplantation
Mesh:Male
Mesh:Middle Aged
Mesh:Models
Mesh:Statistical
Mesh:Registries
Mesh:Regression Analysis
Mesh:Renal Dialysis/mortality
Mesh:Risk Factors
Mesh:Survival Analysis
Mesh:Waiting Lists
Mesh:Aged
survival analysis
multi-state model
renal dialysis
kidney transplantation
03 medical and health sciences
Renal Dialysis
medicine
Humans
MESH: multi-state model
0101 mathematics
MESH: Statistical
Dialysis
Survival analysis
Aged
Models, Statistical
MESH: Humans
business.industry
medicine.disease
Survival Analysis
MESH: Male
Transplantation
business
MESH: Female
MESH: Kidney Transplantation
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 09175040 and 13499092
- Database :
- OpenAIRE
- Journal :
- Journal of Epidemiology, Journal of Epidemiology, Japan Epidemiological Association, 2015, 25 (2), pp.133-141. ⟨10.2188/jea.JE20130193⟩, Journal of Epidemiology, 2015, 25 (2), pp.133-141. ⟨10.2188/jea.JE20130193⟩
- Accession number :
- edsair.doi.dedup.....9a41f9c34feeff9fd5b256936c1e546c