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Saphenous vein thrombophlebitis (SVT): A deceptively benign disease
- Source :
- Journal of Vascular Surgery. 27(4):677-680
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Purpose: The association between deep vein thrombosis (DVT) and the hypercoagulable state is a well-established entity. However, the association between saphenous vein thrombophlebitis and coagulation abnormalities has not been investigated. Although thrombosis of varicose veins typically runs a benign course, phlebitis of the saphenous system may propagate to the deep system or saphenofemoral junction that requires more aggressive therapy. Given the potential similarity in clinical outcome between saphenous vein thrombophlebitis (SVT) and DVT, we have investigated the coagulation profile of patients presenting with isolated SVT. Methods: Seventeen consecutive patients who presented to our vascular laboratory with isolated SVT had a coagulation profile performed that included antithrombin III (AT III), protein C (PC), protein S (PS) antigen and activity levels, activated protein C (APC) resistance, factor V DNA mutation, and coagulation factors II and X. All patients had duplex scans performed on both the superficial and deep venous systems. Patients with SVT only were treated with nonsteroidal antiinflammatory drugs (NSAIDs) and warm soaks as outpatients, whereas those patients found to have DVT or a clot at the saphenofemoral junction were fully anticoagulated with heparin and coumadin therapy. All 17 patients had at least one repeat coagulation profile performed up to 5 months after their SVT occurrence to ensure that the results of hypercoagulability were not transient. Results: Ten (59%) of the 17 patients with SVT had abnormal coagulation profiles on initial presentation. All 10 patients who were hypercoagulable had repeat tests and 6 (35%) remained abnormal. Four patients who had abnormal results converted to normal values. Seven patients with normal coagulation profiles on initial presentation had repeat tests and all remained normal. Conclusion: The incidence of the hypercoagulable state in patients with SVT is high. Thirty-five percent of patients with isolated SVT had consistently abnormal coagulation profiles. Patients with SVT may be prone to the development of DVT or saphenofemoral junction thrombophlebitis and should be closely followed after the initial diagnosis of hypercoagulability. (J Vasc Surg 1998;27:677-80.)
- Subjects :
- Male
Deep vein
Thrombophlebitis
Gastroenterology
Protein S
Ambulatory Care
Ultrasonography, Doppler, Duplex
biology
Incidence
Antithrombin
Anti-Inflammatory Agents, Non-Steroidal
Factor V
Blood Coagulation Disorders
Middle Aged
Thrombosis
medicine.anatomical_structure
Treatment Outcome
Female
Prothrombin
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.drug
Adult
medicine.medical_specialty
Serine Proteinase Inhibitors
Antithrombin III
Postphlebitic Syndrome
Varicose Veins
Fibrinolytic Agents
Internal medicine
Varicose veins
medicine
Humans
Saphenous Vein
Antigens
Aged
business.industry
Vascular disease
Heparin
Anticoagulants
DNA
Femoral Vein
medicine.disease
Surgery
Hemostasis
Factor X
Mutation
biology.protein
Warfarin
business
Phlebitis
Follow-Up Studies
Protein C
Subjects
Details
- ISSN :
- 07415214
- Volume :
- 27
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Vascular Surgery
- Accession number :
- edsair.doi.dedup.....9a3db38c09d2926ab6c4bf660ddbdd0a
- Full Text :
- https://doi.org/10.1016/s0741-5214(98)70233-2