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Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs
- Source :
- Nucleic Acids Research
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- We report the characterization in the human genome of 966 pseudogenes derived from the four human Y (hY) RNAs, components of the Ro/SS-A autoantigen. About 95% of the Y RNA pseudogenes are found in corresponding locations on the chimpanzee and human chromosomes. On the contrary, Y pseudogenes in mice are both infrequent and found in different genomic regions. In addition to this rodent/primate discrepancy, the conservation of hY pseudogenes relative to hY genes suggests that they occurred after rodent/primate divergence. Flanking regions of hY pseudogenes contain convincing evidence for involvement of the L1 retrotransposition machinery. Although Alu elements are found in close proximity to most hY pseudogenes, these are not chimeric retrogenes. Point mutations in hY RNA transcripts specifically affecting binding of Ro60 protein likely contributed to their selection for direct trans retrotransposition. This represents a novel requirement for the selection of specific RNAs for their genomic integration by the L1 retrotransposition machinery. Over 40% of the hY pseudogenes are found in intronic regions of protein-coding genes. Considering the functions of proteins known to bind subsets of hY RNAs, hY pseudogenes constitute a new class of L1-dependent non-autonomous retroelements, potentially involved in post-transcriptional regulation of gene expression.
- Subjects :
- Pan troglodytes
Pseudogene
Molecular Sequence Data
Alu element
Retrotransposon
Biology
Autoantigens
Article
Evolution, Molecular
Mice
03 medical and health sciences
0302 clinical medicine
Gene Duplication
RNA, Small Cytoplasmic
Gene duplication
Genetics
Animals
Humans
Gene
030304 developmental biology
0303 health sciences
Base Sequence
Y RNA
Chromosome Mapping
Computational Biology
RNA
Genomics
Long Interspersed Nucleotide Elements
Ribonucleoproteins
Mutation
Nucleic Acid Conformation
Human genome
Pseudogenes
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13624962
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Research
- Accession number :
- edsair.doi.dedup.....9a04b26ddb52802a3eeace5dd4f660fd