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Is procalcitonin a marker of invasive bacterial infection in acute sickle-cell vaso-occlusive crisis?
- Source :
- Infection. 39(1)
- Publication Year :
- 2010
-
Abstract
- Fever is often present during painful vaso-occlusive crisis (VOC) in sickle-cell disease (SCD), but does not always indicate infection. The aim of our study was to test procalcitonin as a marker of invasive bacterial infection in VOC. Consecutive SCD adults hospitalized for VOC were included. Data were collected at admission and within 24 h after the onset of fever. We distinguished patients with clinically defined and microbiologically documented invasive bacterial infection from patients with no evidence of invasive bacterial infection and who fared well without antibiotics. One hundred and twelve patients were enrolled (61% females, median age 23 years, 88% homozygous SCD). All patients with procalcitonin (PCT) level ≥1 μg/L had an invasive bacterial infection, but two patients (33%) with an invasive bacterial infection had a PCT level
- Subjects :
- Microbiology (medical)
Adult
Calcitonin
Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
medicine.drug_class
Anemia
Calcitonin Gene-Related Peptide
Antibiotics
Disease
Anemia, Sickle Cell
Gastroenterology
Procalcitonin
Predictive Value of Tests
Internal medicine
Medicine
Humans
Prospective Studies
Protein Precursors
Prospective cohort study
business.industry
General Medicine
Bacterial Infections
medicine.disease
Sickle cell anemia
Infectious Diseases
Predictive value of tests
Immunology
Female
business
Vaso-occlusive crisis
hormones, hormone substitutes, and hormone antagonists
Biomarkers
Subjects
Details
- ISSN :
- 14390973
- Volume :
- 39
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Infection
- Accession number :
- edsair.doi.dedup.....99ebe13bc433415e48b9d01c4a86ffd7