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An Inflammation-Immunity Classifier of 11 Chemokines for Prediction of Overall Survival in Head and Neck Squamous Cell Carcinoma
- Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Publication Year :
- 2019
- Publisher :
- International Scientific Literature, Inc., 2019.
-
Abstract
- BACKGROUND Chemokines are important in inflammation, immunity, tumor progression, and metastasis. The purpose of this research was to find an integrated-RNA signature of chemokine family genes to predict the survival prognosis in head and neck squamous carcinoma (HNSC) patients. MATERIAL AND METHODS Relevant data of 504 HNSC patients were extracted from The Cancer Genome Atlas (TCGA) database. Through analyzing RNA sequencing data, the univariate Cox model was used to identify chemokine family genes associated with survival and then to develop a multiple-RNA signature in the training set. The prediction value of this multiple-RNA signature was further verified in the validation and entire sets. The receiver operating characteristic curves were used to assess the predictive value of this multiple-RNA signature. RESULTS Eleven chemokines were included in this prognostic signature. Based on this 11-chemokine signature, we further categorized patients as high or low risk. Compared with low-risk patients, high-risk patients had shorter overall survival (OS) time in the training set [hazard ratio (HR)=3.497, 95% confidence interval (CI)=2.142-5.711, p
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Clinical Research
Internal medicine
Databases, Genetic
medicine
Carcinoma
Biomarkers, Tumor
Humans
Survival analysis
Aged
Proportional Hazards Models
Aged, 80 and over
Receiver operating characteristic
Proportional hazards model
business.industry
Squamous Cell Carcinoma of Head and Neck
Gene Expression Profiling
Hazard ratio
General Medicine
Middle Aged
medicine.disease
Prognosis
Head and neck squamous-cell carcinoma
Survival Analysis
Confidence interval
Squamous carcinoma
ROC Curve
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Chemokines, CC
Carcinoma, Squamous Cell
Female
Chemokines
business
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 16433750 and 12341010
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Accession number :
- edsair.doi.dedup.....99e2d1a78a2a27639d77cc2194f8581d