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Severe acute respiratory syndrome-coronavirus-2: Current advances in therapeutic targets and drug development
- Source :
- Reviews in Medical Virology
- Publication Year :
- 2020
-
Abstract
- Summary The current pandemic of severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) has quickly emerged as a global health concern with government bodies worldwide taking drastic control measures. Understanding the virology of SARS‐CoV‐2, its molecular mechanisms, and its pathogenesis are required for a targeted therapeutic approach. In this review, we highlight the current molecular and drug advances that target SARS‐CoV‐2 at the genome level. We also summarize studies that therapeutically target the host angiotensin‐converting enzyme 2 and proteases. Finally, we summarize antibody‐mediated therapeutic approaches, as well as recent trends in vaccine development. Hence, the purpose of this study is to investigate different molecular targets in SARS‐CoV‐2 pathogenesis and their usefulness in developing strategies for drug development.
- Subjects :
- 0301 basic medicine
Drug
media_common.quotation_subject
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030106 microbiology
ACE2
Review
virus
Bioinformatics
Antibodies, Viral
Antiviral Agents
SARS‐CoV‐2
Pathogenesis
03 medical and health sciences
Therapeutic approach
Virology
Pandemic
Drug Discovery
Global health
Medicine
Humans
antibodies
Protease Inhibitors
Drug Approval
Coronavirus 3C Proteases
COVID-19 Serotherapy
TMPRSS2
media_common
business.industry
SARS-CoV-2
United States Food and Drug Administration
Serine Endopeptidases
Immunization, Passive
Antibodies, Monoclonal
COVID-19
United States
COVID-19 Drug Treatment
030104 developmental biology
Infectious Diseases
Drug development
Gene Expression Regulation
vaccine development
Host-Pathogen Interactions
Spike Glycoprotein, Coronavirus
Molecular targets
Angiotensin-Converting Enzyme 2
business
Subjects
Details
- ISSN :
- 10991654
- Volume :
- 31
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Reviews in medical virology
- Accession number :
- edsair.doi.dedup.....99dfc5e38619f07abc8d76731d90d1b9