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MR imaging techniques for nano-pathophysiology and theranostics
- Source :
- Advanced Drug Delivery Reviews. 74:75-94
- Publication Year :
- 2014
- Publisher :
- Elsevier B.V, 2014.
-
Abstract
- The advent of nanoparticle DDSs (drug delivery systems, nano-DDSs) is opening new pathways to understanding physiology and pathophysiology at the nanometer scale. A nano-DDS can be used to deliver higher local concentrations of drugs to a target region and magnify therapeutic effects. However, interstitial cells or fibrosis in intractable tumors, as occurs in pancreatic or scirrhous stomach cancer, tend to impede nanoparticle delivery. Thus, it is critical to optimize the type and size of nanoparticles to reach the target. High-resolution 3D imaging provides a means of “seeing” the nanoparticle distribution and therapeutic effects. We introduce the concept of “nano-pathophysiological imaging” as a strategy for theranostics. The strategy consists of selecting an appropriate nano-DDS and rapidly evaluating drug effects in vivo to guide the next round of therapy. In this article we classify nano-DDSs by component carrier materials and present an overview of the significance of nano-pathophysiological MRI.
- Subjects :
- Gd-DTPA-PE
Activatable
Pharmaceutical Science
Contrast Media
Nanotechnology
DDS
Drug Delivery Systems
Medicine
Animals
Humans
Longitudinal Relaxation Time
Cancer
business.industry
technology, industry, and agriculture
Theranostics
Mr imaging
Magnetic Resonance Imaging
Transverse Relaxation Time
Drug delivery
In vivo imaging
Multimodal
Nanoparticles
business
Preclinical imaging
MRI
Subjects
Details
- Language :
- English
- ISSN :
- 0169409X
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Advanced Drug Delivery Reviews
- Accession number :
- edsair.doi.dedup.....99d668dfdaf18420313943c476016151