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Gastrointestinal motility, gut hormone secretion, and energy intake after oral loads of free fatty acid or triglyceride in older and middle-aged men
- Source :
- Appetite. 132
- Publication Year :
- 2018
-
Abstract
- In young individuals, oral free fatty acid delays gastric emptying, promotes gut hormone release, and reduces energy intake more than an isocaloric load of triglyceride does. The objective of this study was to compare the effects of the free fatty acid oleic acid (OA) and the triglyceride olive oil (OO) on gastrointestinal motility, gut hormone secretion, and energy intake in older and middle-aged healthy volunteers. In a double-blind, randomized, cross-over, study 10 older (age 83.0 ± 3.4 (mean ± SD) years) and 10 middle-aged (age 43.1 ± 8.9 years) men were examined on two occasions to evaluate the effect of isocaloric and isovolaemic loads of radiolabelled OA or OO on gastric emptying, oro-caecal transit, glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) secretions, and energy intake. Gastric emptying was slower in older than in middle-aged men (lipid p 0.001, water p = 0.010), while no difference between these groups was found for oro-caecal transit. In comparison with OO, OA caused slower gastric emptying (lipid p 0.001, water p = 0.020) and faster oro-caecal transit (p = 0.025). Postprandial secretion of GLP-1 and PYY was comparable for older and middle-aged men, as well as for OA and OO. Older men ingested less energy than middle-aged men did (p 0.001) and their energy intake was lower after OA than OO (p = 0.002). Thus, gastric emptying of an oral lipid load is slower in older than in middle-aged men; gastric emptying is slower and oro-caecal transit faster after OA than OO in both age groups; and older men ingest less energy than middle-aged men and less energy after OA than OO.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Motility
Administration, Oral
030209 endocrinology & metabolism
Fatty Acids, Nonesterified
Gastrointestinal Hormones
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Double-Blind Method
Glucagon-Like Peptide 1
Internal medicine
Medicine
Humans
Secretion
Peptide YY
Olive Oil
General Psychology
Triglycerides
Aged
chemistry.chemical_classification
Aged, 80 and over
030109 nutrition & dietetics
Nutrition and Dietetics
Triglyceride
Gastric emptying
business.industry
digestive, oral, and skin physiology
Fatty acid
Middle Aged
Oleic acid
Endocrinology
chemistry
Gastric Emptying
business
Energy Intake
Gastrointestinal Motility
Hormone
Oleic Acid
Subjects
Details
- ISSN :
- 10958304
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Appetite
- Accession number :
- edsair.doi.dedup.....99b7b1a022c32a39d5818f6d148df0af