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Characterizing cannabis-induced psychosis: A study with prepulse inhibition of the startle reflex
- Source :
- Psychiatry Research. 220:535-540
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Cannabis-induced psychotic disorder (CIPD) refers to psychotic symptoms that arise in the context of cannabis intoxication. Prepulse inhibition (PPI) deficits have been extensively identified in schizophrenia and in cannabis abusers. We aimed to characterize PPI in CIPD patients. We used a sample of 48 CIPD patients, 54 schizophrenia patients and cannabis abuse (SCHZ), 44 cannabis dependents (CD), and 44 controls. CIPD, SCHZ and CD were abstinent of cannabis consumption for 9 months. Participants were assessed with PPI at 30, 60, and 120 ms. At 30 ms, CIPD showed lower PPI levels than controls, and SCHZ obtained worse functioning than controls and CD. At 60 ms, only SCHZ exhibited worse PPI percentages (of object) than controls. Finally, at 120 ms, CIPD showed higher PPI levels than SCHZ, and SCHZ obtained lower percentages than controls. We found that CIPD and SCHZ patients showed deficits at the most pre-attentional levels, whereas CIPD patients performed better than SCHZ at higher attentional levels. These results suggest that CIPD constitutes a different group of patients than that of SCHZ. Deficits in PPI functioning at 30 ms could be a useful psychophysiological measure to detect CIPD patients, who are frequently confused with cannabis abusers whose symptoms may mimic that of schizophrenia.
- Subjects :
- Adult
Male
Marijuana Abuse
Reflex, Startle
medicine.medical_specialty
Context (language use)
Audiology
Psychoses, Substance-Induced
Cannabis intoxication
Young Adult
Moro reflex
Cannabis abuse
medicine
Humans
Attention
Psychiatry
Biological Psychiatry
Prepulse inhibition
Cannabis
Induced psychosis
biology
Prepulse Inhibition
biology.organism_classification
medicine.disease
Psychiatry and Mental health
Schizophrenia
Female
Schizophrenic Psychology
Psychology
Subjects
Details
- ISSN :
- 01651781
- Volume :
- 220
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research
- Accession number :
- edsair.doi.dedup.....99ad6a3f44ea339fd602a7ffae7dd2c2