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The role of bile acid subtypes in the diagnosis of cholangiocarcinoma
- Source :
- Asia-Pacific journal of clinical oncologyREFERENCES. 18(2)
- Publication Year :
- 2021
-
Abstract
- OBJECTIVES To find the potential biomarkers of cholangiocarcinoma, form a biomarker package, evaluate its efficiency, and validate it. METHODS R software was used to analyze the differential expression of mRNAs between cholangiocarcinoma and adjacent nontumorous tissues, obtained from The Cancer Genome Atlas (TCGA), and enrich the KEGG pathway. Metabo-Profile Inc. performed the comprehensive bile acid profiling and quantitation. The training set concluded 20 cholangiocarcinoma and 20 nontumorous volunteers. Receiver operating characteristic (ROC) curve and accompanying area under the curve (AUC) was calculated. The top four bile acids formed a new biomarker package. The validation set included 15 cholangiocarcinoma and 15 nontumorous, and the sensitivity and specificity of the new biomarker package were tested. RESULTS Gene expression of 36 cholangiocarcinoma and nine adjacent nontumorous tissues was obtained in January 2020. Totally 9887 differential genes were eligible (logFC ≥ 1 or ≤ -1, P
- Subjects :
- medicine.drug_class
Population
digestive system
Bile Acids and Salts
Cholangiocarcinoma
03 medical and health sciences
0302 clinical medicine
Gene expression
Biomarkers, Tumor
Medicine
Bile
Humans
030212 general & internal medicine
KEGG
education
neoplasms
Gene
education.field_of_study
Bile acid
Receiver operating characteristic
business.industry
Area under the curve
General Medicine
Bile Ducts, Intrahepatic
Oncology
Bile Duct Neoplasms
ROC Curve
030220 oncology & carcinogenesis
Cancer research
Biomarker (medicine)
business
Subjects
Details
- ISSN :
- 17437563
- Volume :
- 18
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Asia-Pacific journal of clinical oncologyREFERENCES
- Accession number :
- edsair.doi.dedup.....999f6ea3fb48938d6421c92b570d7390