Back to Search
Start Over
Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn
- Source :
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 260(4)
- Publication Year :
- 2021
-
Abstract
- Purpose The lacrimal caruncle is composed of numerous structures including different glands as well as hair follicles. Accordingly, the spectrum of benign and malignant lesions is broad, and the clinical diagnosis is often challenging. Here we systematically analyzed excised caruncular tumors over the past 22 years with special emphasis on the clinico-pathological correlation to provide a guidance for clinicians. Methods Retrospective evaluation with clinico-pathologic correlation of surgically removed caruncular tumors between 1998 and 2020 at a tertiary referral center. Results Eighty-two caruncular tumors were identified in the respective period. The patients were between 11 and 85 years of age (mean, 46.8 years; median, 49 years). Nevi (n = 35), cystic lesions (n = 14), oncocytoma (n = 9), papilloma (n = 8), sebaceous gland hyperplasia (n = 8), and reactive lymphoid hyperplasia (n = 4) were observed most frequently. Besides, we are the first reporting herniated orbital fat accompanied by a pyogenic granuloma. 2.4% (n = 2) were malignant tumors (sebaceous gland carcinoma, conjunctival intraepithelial neoplasia with pyogenic granuloma). Conclusion Caruncular tumors show a broad spectrum of mostly benign tumors. They can occur in patients of any age. However, 8/9 oncocytomas and both malignant lesions were detected in patients older than 60 years. Although the clinical diagnosis was confirmed in only 68.3% by the histopathological analysis, the two malignant lesions were identified as such already clinically. Caruncular lesions with a history of growth or other signs of malignancy should be excised followed by detailed histopathological examination to allow a final diagnosis and exclude rare malignant tumors with lethal potential.
- Subjects :
- Pathology
medicine.medical_specialty
Skin Neoplasms
Universities
business.industry
Pyogenic granuloma
Middle Aged
medicine.disease
Malignancy
Sensory Systems
Lymphoid hyperplasia
Hospitals
Lacrimal caruncle
Cellular and Molecular Neuroscience
Ophthalmology
medicine
Nevus
Papilloma
Humans
Oncocytoma
Sebaceous gland carcinoma
Sebaceous Gland Neoplasms
medicine.symptom
business
Retrospective Studies
Subjects
Details
- ISSN :
- 1435702X
- Volume :
- 260
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
- Accession number :
- edsair.doi.dedup.....999378665eebc7203c0fb6c2e6d8bdd4