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Searching for selected VOCs in human breath samples as potential markers of lung cancer
- Source :
- Lung Cancer. 135:123-129
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Objective: Evaluation of the potential of combined multivariate chemometric methods for seeking markers of lung cancer. Methods: Statistical methods such as Mann-Whitney U test, discriminant function analysis (DFA), factor analysis (FA) and artificial neural network (ANN) were applied to evaluate the obtained data from GC/MS analysis of exhaled breath. Results: The total number of compounds identified by GC/MS in human breath was equal to 88. The statistical analysis indicates seven analytes which have the highest discriminatory power. Cross validation of the obtained model shows that the sensitivity was 80% and the specificity was 91.23%, while for the test group the sensitivity and specificity were both 86.36%. Conclusion: The application of combined statistical methods allowed to reduce the number of compounds to significant ones and indicates them as markers of lung cancer.
- Subjects :
- Adult
Male
0301 basic medicine
Pulmonary and Respiratory Medicine
Oncology
Cancer Research
Analyte
Multivariate statistics
medicine.medical_specialty
Lung Neoplasms
Test group
Gas Chromatography-Mass Spectrometry
Cross-validation
03 medical and health sciences
0302 clinical medicine
Discriminant function analysis
Internal medicine
Biomarkers, Tumor
Humans
Medicine
Statistical analysis
Lung cancer
Aged
Aged, 80 and over
Volatile Organic Compounds
business.industry
Discriminant Analysis
Middle Aged
medicine.disease
030104 developmental biology
Breath Tests
ROC Curve
Exhalation
030220 oncology & carcinogenesis
Mann–Whitney U test
Female
Neural Networks, Computer
business
Subjects
Details
- ISSN :
- 01695002
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Lung Cancer
- Accession number :
- edsair.doi.dedup.....999366d811400bd81f7c49220aae966f