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Efficacy and Interindividual Variability in Motor-Cortex Plasticity following Anodal tDCS and Paired-Associative Stimulation
- Source :
- Neural Plasticity, Vol 2015 (2015), Neural Plasticity
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Interindividual response variability to various motor-cortex stimulation protocols has been recently reported. Comparative data of stimulation protocols with different modes of action is lacking. We aimed to compare the efficacy and response variability of two LTP-inducing stimulation protocols in the human motor cortex: anodal transcranial direct current stimulation (a-tDCS) and paired-associative stimulation (PAS25). In two experiments 30 subjects received 1mA a-tDCS and PAS25. Data analysis focused on motor-cortex excitability change and response defined as increase in MEP applying different cut-offs. Furthermore, the predictive pattern of baseline characteristics was explored. Both protocols induced a significant increase in motor-cortical excitability. In the PAS25 experiments the likelihood to develop a MEP response was higher compared to a-tDCS, whereas for intracortical facilitation (ICF) the likelihood for a response was higher in the a-tDCS experiments. Baseline ICF (12 ms) correlated positively with an increase in MEPs only following a-tDCS and responders had significantly higher ICF baseline values. Contrary to recent studies, we showed significant group-level efficacy following both stimulation protocols confirming older studies. However, we also observed a remarkable amount of nonresponders. Our findings highlight the need to define sufficient physiological read-outs for a given plasticity protocol and to develop predictive markers for targeted stimulation.
- Subjects :
- Adult
Male
Anodal tdcs
Article Subject
medicine.medical_treatment
Stimulation
Plasticity
Transcranial Direct Current Stimulation
lcsh:RC321-571
Paired associative stimulation
Young Adult
Neuroplasticity
medicine
Humans
ddc:610
Peripheral Nerves
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Neuronal Plasticity
Transcranial direct-current stimulation
Motor Cortex
Evoked Potentials, Motor
Response Variability
Electric Stimulation
medicine.anatomical_structure
Neurology
Female
Neurology (clinical)
Psychology
Corrigendum
Neuroscience
Motor cortex
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 16875443 and 20905904
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Neural Plasticity
- Accession number :
- edsair.doi.dedup.....998b235acbeeb58e24be9896ff8a16d2