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Higher acyclic nitrogen containing deoxy sugar derivatives: A new lead in the generation of antimycobacterial chemotherapeutics
- Source :
- Bioorganic & Medicinal Chemistry. 10:1695-1702
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Syntheses of higher acyclic nitrogen containing deoxy sugar derivatives via nitroaldol reaction of different nitroalkanes with 2,3-dideoxy-alpha,beta-unsaturated aldehydo sugars obtained from glycals namely acetylated glucal and galactal and their in vitro antimycobacterial activity are presented.
- Subjects :
- Nitroaldol reaction
Nitrogen
medicine.drug_class
Clinical Biochemistry
Antitubercular Agents
Nitro compound
Pharmaceutical Science
Carboxamide
Microbial Sensitivity Tests
Antimycobacterial
Biochemistry
Chemical synthesis
Structure-Activity Relationship
chemistry.chemical_compound
Deoxy Sugars
Drug Discovery
medicine
Organic chemistry
Deoxy sugar
Molecular Biology
Glucal
Antibacterial agent
chemistry.chemical_classification
Molecular Structure
Organic Chemistry
Acetylation
Mycobacterium tuberculosis
chemistry
Molecular Medicine
Hydrogenation
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....998acc80ad03d28306d2c193481c4f97
- Full Text :
- https://doi.org/10.1016/s0968-0896(02)00045-7