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A workflow for patient-specific fluid–structure interaction analysis of the mitral valve: A proof of concept on a mitral regurgitation case
- Source :
- Medical Engineering & Physics. 74:153-161
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The mechanics of the mitral valve (MV) are the result of the interaction of different anatomical structures complexly arranged within the left heart (LH), with the blood flow. MV structure abnormalities might cause valve regurgitation which in turn can lead to heart failure. Patient-specific computational models of the MV could provide a personalised understanding of MV mechanics, dysfunctions and possible interventions. In this study, we propose a semi-automatic pipeline for MV modelling based on the integration of state-of-the-art medical imaging, i.e. cardiac magnetic resonance (CMR) and 3D transoesophageal-echocardiogram (TOE) with fluid-structure interaction (FSI) simulations. An FSI model of a patient with MV regurgitation was implemented using the finite element (FE) method and smoothed particle hydrodynamics (SPH). Our study showed the feasibility of combining image information and computer simulations to reproduce patient-specific MV mechanics as seen on medical images, and the potential for efficient in-silico studies of MV disease, personalised treatments and device design.
- Subjects :
- Male
Patient-Specific Modeling
Computer science
Finite Element Analysis
0206 medical engineering
Biomedical Engineering
Biophysics
02 engineering and technology
Regurgitation (circulation)
Workflow
Electrocardiography
03 medical and health sciences
0302 clinical medicine
Mitral valve
Fluid–structure interaction
Image Processing, Computer-Assisted
medicine
Medical imaging
Humans
Mitral regurgitation
Hemodynamics
Mitral Valve Insufficiency
Blood flow
Middle Aged
medicine.disease
Magnetic Resonance Imaging
020601 biomedical engineering
Finite element method
medicine.anatomical_structure
Heart failure
Mitral Valve
030217 neurology & neurosurgery
Biomedical engineering
Subjects
Details
- ISSN :
- 13504533
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Medical Engineering & Physics
- Accession number :
- edsair.doi.dedup.....9989d8f701b4329d7221559e44717745