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Quantitative assessment of finger motor impairment in multiple sclerosis
- Source :
- PLoS ONE, Vol 8, Iss 5, p e65225 (2013), PLoS ONE
- Publication Year :
- 2013
-
Abstract
- Objective To address the disability impact on fine hand motor functions in patients with Multiple Sclerosis (MS) by quantitatively measuring finger opposition movements, with the aim of providing a new “score” integrating current methods for disability assessment. Methods 40 MS patients (Expanded Disability Status Scale (EDSS): 0–7) and 80 healthy controls (HC) performed a repetitive finger-to-thumb opposition sequence with their dominant hand at spontaneous and maximal velocity, and uni- and bi-manually metronome-paced. A sensor-engineered glove was used to measure finger motor performance. Twenty-seven HC were tested twice, one month apart, to assess test-retest reliability. Results The motor parameters showed a good reproducibility in HC and demonstrated significantly worse performance in MS patients with respect to HC. A multivariate model revealed that rate of movement in the spontaneous velocity condition and inter-hand interval (IHI), indicating bimanual coordination, contributed independently to differentiate the two groups. A finger motor impairment score based on these two parameters was able to discriminate HC from MS patients with very low EDSS scores (p
- Subjects :
- Adult
Male
Gerontology
medicine.medical_specialty
Anatomy and Physiology
Multiple Sclerosis
Psychometrics
lcsh:Medicine
Neurological System
Motor Neuron Diseases
Fingers
Young Adult
Physical medicine and rehabilitation
Diagnostic Medicine
Neurobiology of Disease and Regeneration
Pathology
Quantitative assessment
Humans
Medicine
Young adult
lcsh:Science
Biology
Aged
Reproducibility
Movement Disorders
Multidisciplinary
Expanded Disability Status Scale
business.industry
Multiple sclerosis
lcsh:R
Case-control study
Reproducibility of Results
Motor impairment
Middle Aged
medicine.disease
Demyelinating Disorders
Neurology
ROC Curve
Case-Control Studies
Female
lcsh:Q
business
Psychomotor Performance
Research Article
Neuroscience
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 8, Iss 5, p e65225 (2013), PLoS ONE
- Accession number :
- edsair.doi.dedup.....99881f32a81fbf80afc2a779729109f5